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Risk factors for the different types of chronic lung diseases of prematurity according to the preceding respiratory distress syndrome

Cited 17 time in Web of Science Cited 16 time in Scopus
Authors
Choi, C. W.; Kim, B. I.; Park, J. D.; Koh, Y. Y.; Choi, J. H.; Choi, J. Y.
Issue Date
2005-08-11
Publisher
Wiley-Blackwell
Citation
Pediatr Int. 2005 Aug;47(4):417-23.
Keywords
Chorioamnionitis/epidemiologyChronic DiseaseFemaleGestational AgeHumansInfant, NewbornInfant, PrematureInfant, Premature, Diseases/*epidemiologyLogistic ModelsLung Diseases/*epidemiologyMalePregnancyRespiratory Distress Syndrome, Newborn/*epidemiologyRisk Factors
Abstract
BACKGROUND: Recently, atypical chronic lung disease (CLD) of prematurity that develops in the absence of preceding respiratory distress syndrome (RDS) have been observed frequently. The specific risk factors for atypical CLD that are presumed to be different from those for classical CLD that develops following RDS were assessed. METHODS: Prospective cohort analysis was done from 115 very low-birthweight infants who were born in Seoul National University Hospital, Seoul, Korea, and survived more than 36 weeks postmenstrual age or 28 days of life. All subjects were classified into either a preceding RDS group (n = 35) or a non-RDS group (n = 80). Logistic regression analysis was done for the multivariate assessment of specific risk factors for CLD in both groups. RESULTS: The analysis showed that short gestational age (GA; relative risk [RR], 3.1 per 1 week decrement; 95% confidence intervals [CI], 2.7-3.4), of the male gender (RR, 9.8; CI, 0.9-112), and poor response to surfactant (RR, 14; CI, 1.2-156) were significant risk factors for CLD in the preceding RDS group. In the non-RDS group, chorioamnionitis was one of the significant risk factors for CLD (RR, 4.8; CI, 1.1-21) along with short GA and high mean airway pressure (MAP) during the first 3 days of life. CONCLUSION: Chorioamnionitis was a risk factor for atypical CLD in addition to short GA and high MAP during the early postnatal period, and poor response to surfactant was a risk factor for classical CLD in addition to short GA and being male. Therefore, CLD is considered to have type-specific risk factors.
ISSN
1328-8067 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16091080

http://hdl.handle.net/10371/22645
DOI
https://doi.org/10.1111/j.1442-200x.2005.02081.x
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College of Medicine/School of Medicine (의과대학/대학원)Immunology (면역학전공)Journal Papers (저널논문_면역학전공)
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