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UVB-induced interleukin-18 production is downregulated by tannic acids in human HaCaT keratinocytes

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dc.contributor.authorPark, H. J.-
dc.contributor.authorKim, H. J.-
dc.contributor.authorKwon, H. J.-
dc.contributor.authorLee, J. Y.-
dc.contributor.authorCho, B. K.-
dc.contributor.authorLee, W. J.-
dc.contributor.authorYang, Y.-
dc.contributor.authorCho, D. H.-
dc.date.accessioned2009-12-28T02:29:53Z-
dc.date.available2009-12-28T02:29:53Z-
dc.date.issued2006-07-18-
dc.identifier.citationExp Dermatol. 2006 Aug;15(8):589-95.en
dc.identifier.issn0906-6705 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16842597-
dc.identifier.urihttp://hdl.handle.net/10371/22837-
dc.description.abstractTannic acids (TAs) are believed to be the key active components in plants, and are believed to be responsible for their anti-inflammatory, anti-viral effects and chemoprevention of cancer. However, the molecular mechanisms for the action of TA are unclear. This study examined the effects of TA on cutaneous inflammation with a human keratinocyte cell line (HaCaT). Interleukin-18 (IL-18) has multiple effects upon various cells involved in inflammatory response. In this study, the IL-18 mRNA expression and protein levels were reduced by a TA pretreatment. UV radiation can trigger the induction of the p38 mitogen-activated protein kinase (MAPK)-dependent signalling cascade. Immunoprecipitation and Western blot analysis was performed to determine if TA regulate the MAPK signalling pathway. TA significantly inhibited the activation of p38 MAPK and extracellular signal-regulated protein kinases. Moreover, TA-inhibited UVB enhanced the expression of the inflammatory mediators, IL-1, IL-6, tumor necrotic factor-alpha, cyclooxygenase-2 and prostaglandin E(2) in UVB-irradiated HaCaT cells. The topical application of TA on mouse skin treated with UVB irradiation has shown that TA inhibited the formation of erythema. These findings suggest that TA has significant anti-inflammatory effects on the UVB-induced response on the skin and may be a candidate natural compound for the regulation of cutaneous inflammation.en
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.subjectAnimalsen
dc.subjectCells, Cultureden
dc.subject*Down-Regulationen
dc.subjectErythema/metabolismen
dc.subjectDinoprostone/metabolismen
dc.subjectHumansen
dc.subjectInflammationen
dc.subjectInterleukin-18/*biosynthesis/metabolismen
dc.subjectKeratinocytes/metabolismen
dc.subjectMAP Kinase Signaling Systemen
dc.subjectMiceen
dc.subjectSkin/metabolism/pathologyen
dc.subjectTannins/*metabolismen
dc.subjectTime Factorsen
dc.subject*Ultraviolet Raysen
dc.titleUVB-induced interleukin-18 production is downregulated by tannic acids in human HaCaT keratinocytesen
dc.typeArticleen
dc.contributor.AlternativeAuthor박현정-
dc.contributor.AlternativeAuthor김희정-
dc.contributor.AlternativeAuthor권현조-
dc.contributor.AlternativeAuthor이준영-
dc.contributor.AlternativeAuthor조백기-
dc.contributor.AlternativeAuthor이왕재-
dc.contributor.AlternativeAuthor양영-
dc.contributor.AlternativeAuthor조대호-
dc.identifier.doi10.1111/j.1600-0625.2006.00449.x-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Anatomy (해부학전공)Journal Papers (저널논문_해부학전공)
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