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GSTM1 and TNF-alpha gene polymorphisms and relations between blood lead and inflammatory markers in a non-occupational population

Cited 15 time in Web of Science Cited 15 time in Scopus
Authors
Kim, Jin Hee; Lee, Kwan-Hee; Yoo, Dong Ho; Kang, Daehee; Cho, Soo-Hun; Hong, Yun-Chul
Issue Date
2007-02-15
Publisher
Elsevier
Citation
Mutat Res. 2007 Apr 20;629(1):32-9. Epub 2007 Jan 13.
Keywords
AdultAllelesBiological Markers/bloodEnzyme-Linked Immunosorbent AssayFemaleGlutathione Transferase/*geneticsHumansInflammation/*bloodInterleukin-6/bloodLead/*bloodLeukocyte CountMalePolymerase Chain Reaction*Polymorphism, GeneticPolymorphism, Restriction Fragment LengthStudentsTumor Necrosis Factor-alpha/blood/*genetics
Abstract
Inflammation is known to be an important underlying condition in the development of a variety of diseases. To investigate whether blood lead induces inflammatory reactions in non-occupationally exposed adults and the effects of genetic susceptibility associated with GSTM1 and TNF-alpha gene polymorphisms on this inflammatory response, we measured blood lead levels in 300 healthy university students. Total serum TNF-alpha and IL-6 levels and WBC counts were determined to evaluate the inflammatory response. Allelic loss of GSTM1 and the TNF-alpha-308 G>A polymorphism were determined by PCR and RFLP. Positive relations between blood lead and three inflammation biomarkers were shown in male subjects with blood lead > or =2.51microg/dl (median value) (TNF-alpha, p=0.015; IL-6, p=0.082; and WBC, p=0.044). However, subgroup analysis by genotype showed an effect of blood lead on the three biomarkers only in individuals with the GSTM1 null (TNF-alpha, p=0.020; IL-6, p=0.096; and WBC, p=0.017) or TNF-alpha GG (TNF-alpha, p=0.017; IL-6, p=0.088; and WBC, p=0.095) genotype, and not in individuals with GSTM1 present (all three inflammatory biomarkers, p>0.1) or the TNF-alpha GA or AA (all three biomarkers, p>0.1) genotype. These results suggest that blood lead affects the inflammatory response and that GSTM1 and TNF-alpha gene polymorphisms are genetic factors associated with lead-induced inflammatory response.
ISSN
0027-5107 (Print)
Language
English
URI
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T2D-4MTC6NK-3&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=a0837fd5084d8792b9082cd6345a9472

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17298885

http://hdl.handle.net/10371/22898
DOI
https://doi.org/10.1016/j.mrgentox.2007.01.004
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College of Medicine/School of Medicine (의과대학/대학원)Program in Cancer Biology (협동과정-종양생물학전공)Journal Papers (저널논문_협동과정-종양생물학전공)
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