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GSTM1 and TNF-alpha gene polymorphisms and relations between blood lead and inflammatory markers in a non-occupational population
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jin Hee | - |
dc.contributor.author | Lee, Kwan-Hee | - |
dc.contributor.author | Yoo, Dong Ho | - |
dc.contributor.author | Kang, Daehee | - |
dc.contributor.author | Cho, Soo-Hun | - |
dc.contributor.author | Hong, Yun-Chul | - |
dc.date.accessioned | 2009-12-29 | - |
dc.date.available | 2009-12-29 | - |
dc.date.issued | 2007-02-15 | - |
dc.identifier.citation | Mutat Res. 2007 Apr 20;629(1):32-9. Epub 2007 Jan 13. | en |
dc.identifier.issn | 0027-5107 (Print) | - |
dc.identifier.uri | http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T2D-4MTC6NK-3&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=a0837fd5084d8792b9082cd6345a9472 | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17298885 | - |
dc.identifier.uri | https://hdl.handle.net/10371/22898 | - |
dc.description.abstract | Inflammation is known to be an important underlying condition in the development of a variety of diseases. To investigate whether blood lead induces inflammatory reactions in non-occupationally exposed adults and the effects of genetic susceptibility associated with GSTM1 and TNF-alpha gene polymorphisms on this inflammatory response, we measured blood lead levels in 300 healthy university students. Total serum TNF-alpha and IL-6 levels and WBC counts were determined to evaluate the inflammatory response. Allelic loss of GSTM1 and the TNF-alpha-308 G>A polymorphism were determined by PCR and RFLP. Positive relations between blood lead and three inflammation biomarkers were shown in male subjects with blood lead > or =2.51microg/dl (median value) (TNF-alpha, p=0.015; IL-6, p=0.082; and WBC, p=0.044). However, subgroup analysis by genotype showed an effect of blood lead on the three biomarkers only in individuals with the GSTM1 null (TNF-alpha, p=0.020; IL-6, p=0.096; and WBC, p=0.017) or TNF-alpha GG (TNF-alpha, p=0.017; IL-6, p=0.088; and WBC, p=0.095) genotype, and not in individuals with GSTM1 present (all three inflammatory biomarkers, p>0.1) or the TNF-alpha GA or AA (all three biomarkers, p>0.1) genotype. These results suggest that blood lead affects the inflammatory response and that GSTM1 and TNF-alpha gene polymorphisms are genetic factors associated with lead-induced inflammatory response. | en |
dc.language.iso | en | - |
dc.publisher | Elsevier | en |
dc.subject | Adult | en |
dc.subject | Alleles | en |
dc.subject | Biological Markers/blood | en |
dc.subject | Enzyme-Linked Immunosorbent Assay | en |
dc.subject | Female | en |
dc.subject | Glutathione Transferase/*genetics | en |
dc.subject | Humans | en |
dc.subject | Inflammation/*blood | en |
dc.subject | Interleukin-6/blood | en |
dc.subject | Lead/*blood | en |
dc.subject | Leukocyte Count | en |
dc.subject | Male | en |
dc.subject | Polymerase Chain Reaction | en |
dc.subject | Polymorphism, Restriction Fragment Length | en |
dc.subject | Students | en |
dc.subject | Tumor Necrosis Factor-alpha/blood/*genetics | en |
dc.subject | Polymorphism, Genetic | - |
dc.title | GSTM1 and TNF-alpha gene polymorphisms and relations between blood lead and inflammatory markers in a non-occupational population | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김진희 | - |
dc.contributor.AlternativeAuthor | 이관희 | - |
dc.contributor.AlternativeAuthor | 유동호 | - |
dc.contributor.AlternativeAuthor | 강대희 | - |
dc.contributor.AlternativeAuthor | 조수현 | - |
dc.contributor.AlternativeAuthor | 홍윤철 | - |
dc.identifier.doi | 10.1016/j.mrgentox.2007.01.004 | - |
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