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A novel function of Nur77: physical and functional association with protein kinase C

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dc.contributor.authorKim, Hyungsoo-
dc.contributor.authorKim, Bu-Yeon-
dc.contributor.authorSoh, Jae-Won-
dc.contributor.authorCho, Eun-Jung-
dc.contributor.authorLiu, Jun O.-
dc.contributor.authorYoun, Hong-Duk-
dc.date.accessioned2009-12-29T01:23:25Z-
dc.date.available2009-12-29T01:23:25Z-
dc.date.issued2006-08-15-
dc.identifier.citationBiochem Biophys Res Commun. 2006 Sep 29;348(3):950-6. Epub 2006 Aug 4.en
dc.identifier.issn0006-291X (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16904076-
dc.identifier.urihttp://hdl.handle.net/10371/22934-
dc.description.abstractDespite the involvement in diverse physiological process and pleiotropic expression profile, the molecular functions of Nur77 are not likely to be fully elucidated. From the effort to find a novel function of Nur77, we detected molecular interaction between Nur77 and PKC. Details of interaction revealed that C-terminal ligand binding domain (LBD) of Nur77 specifically interacted with highly conserved glycine-rich loop of PKC required for catalytic activity. This molecular interaction resulted in inhibition of catalytic activity of PKCtheta by Nur77. C-terminal LBD of Nur77 is sufficient for inhibiting the phosphorylation of substrate by PKCtheta. Ultimately, inhibition of catalytic activity by Nur77 is deeply associated with repression of PKC-mediated activation of AP-1 and NF-kappaB. Therefore, these findings demonstrate a novel function of Nur77 as a PKC inhibitor and give insights into molecular mechanisms of various Nur77-mediated physiological phenomena.en
dc.language.isoen-
dc.publisherElsevieren
dc.subjectAnimalsen
dc.subjectCatalytic Domain/physiologyen
dc.subjectCell Lineen
dc.subjectDNA-Binding Proteins/*chemistry/metabolism/*physiologyen
dc.subjectHumansen
dc.subjectJurkat Cellsen
dc.subjectMiceen
dc.subjectMice, Transgenicen
dc.subjectProtein Kinase C/antagonists & inhibitors/*metabolism/physiologyen
dc.subjectReceptors, Cytoplasmic and Nuclear/*chemistry/metabolism/*physiologyen
dc.subjectReceptors, Steroid/*chemistry/metabolism/*physiologyen
dc.subjectTranscription Factors/*chemistry/metabolism/*physiologyen
dc.subjectTwo-Hybrid System Techniquesen
dc.titleA novel function of Nur77: physical and functional association with protein kinase Cen
dc.typeArticleen
dc.contributor.AlternativeAuthor김형수-
dc.contributor.AlternativeAuthor김부연-
dc.contributor.AlternativeAuthor소재원-
dc.contributor.AlternativeAuthor조은정-
dc.contributor.AlternativeAuthor윤홍덕-
dc.identifier.doi10.1016/j.bbrc.2006.07.167-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Biochemistry & Molecular Biology (생화학교실)Journal Papers (저널논문_생화학교실)
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