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A novel function of Nur77: physical and functional association with protein kinase C
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hyungsoo | - |
dc.contributor.author | Kim, Bu-Yeon | - |
dc.contributor.author | Soh, Jae-Won | - |
dc.contributor.author | Cho, Eun-Jung | - |
dc.contributor.author | Liu, Jun O. | - |
dc.contributor.author | Youn, Hong-Duk | - |
dc.date.accessioned | 2009-12-29T01:23:25Z | - |
dc.date.available | 2009-12-29T01:23:25Z | - |
dc.date.issued | 2006-08-15 | - |
dc.identifier.citation | Biochem Biophys Res Commun. 2006 Sep 29;348(3):950-6. Epub 2006 Aug 4. | en |
dc.identifier.issn | 0006-291X (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16904076 | - |
dc.identifier.uri | https://hdl.handle.net/10371/22934 | - |
dc.description.abstract | Despite the involvement in diverse physiological process and pleiotropic expression profile, the molecular functions of Nur77 are not likely to be fully elucidated. From the effort to find a novel function of Nur77, we detected molecular interaction between Nur77 and PKC. Details of interaction revealed that C-terminal ligand binding domain (LBD) of Nur77 specifically interacted with highly conserved glycine-rich loop of PKC required for catalytic activity. This molecular interaction resulted in inhibition of catalytic activity of PKCtheta by Nur77. C-terminal LBD of Nur77 is sufficient for inhibiting the phosphorylation of substrate by PKCtheta. Ultimately, inhibition of catalytic activity by Nur77 is deeply associated with repression of PKC-mediated activation of AP-1 and NF-kappaB. Therefore, these findings demonstrate a novel function of Nur77 as a PKC inhibitor and give insights into molecular mechanisms of various Nur77-mediated physiological phenomena. | en |
dc.language.iso | en | - |
dc.publisher | Elsevier | en |
dc.subject | Animals | en |
dc.subject | Catalytic Domain/physiology | en |
dc.subject | Cell Line | en |
dc.subject | DNA-Binding Proteins/*chemistry/metabolism/*physiology | en |
dc.subject | Humans | en |
dc.subject | Jurkat Cells | en |
dc.subject | Mice | en |
dc.subject | Mice, Transgenic | en |
dc.subject | Protein Kinase C/antagonists & inhibitors/*metabolism/physiology | en |
dc.subject | Receptors, Cytoplasmic and Nuclear/*chemistry/metabolism/*physiology | en |
dc.subject | Receptors, Steroid/*chemistry/metabolism/*physiology | en |
dc.subject | Transcription Factors/*chemistry/metabolism/*physiology | en |
dc.subject | Two-Hybrid System Techniques | en |
dc.title | A novel function of Nur77: physical and functional association with protein kinase C | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김형수 | - |
dc.contributor.AlternativeAuthor | 김부연 | - |
dc.contributor.AlternativeAuthor | 소재원 | - |
dc.contributor.AlternativeAuthor | 조은정 | - |
dc.contributor.AlternativeAuthor | 윤홍덕 | - |
dc.identifier.doi | 10.1016/j.bbrc.2006.07.167 | - |
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