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Relationship between N-acetyl-aspartate in gray and white matter of abstinent methamphetamine abusers and their history of drug abuse: a proton magnetic resonance spectroscopy study

Cited 52 time in Web of Science Cited 62 time in Scopus
Authors
Sung, Young Hoon; Cho, Soo Churl; Hwang, Jaeuk; Kim, Seog Ju; Kim, Hyungjun; Bae, Sujin; Kim, Namguk; Chang, Kee Hyun; Daniels, Melissa; Renshaw, Perry F; Lyoo, In Kyoon
Issue Date
2007
Publisher
Elsevier
Citation
Drug Alcohol Depend. 88, 28-35
Keywords
Amphetamine-Related Disorders/*metabolism/*pathologyAnalysis of VarianceAspartic Acid/*analogs & derivatives/analysisBasal Ganglia/pathologyCholine/analysisCreatine/analysisFrontal Lobe/pathologyInositol/analysisKorea*Magnetic Resonance SpectroscopyMethamphetamine/*adverse effectsNeurotoxins/metabolismProtonsTime Factors
Abstract
OBJECTIVE: Altered concentrations of the brain metabolites, including N-acetyl-aspartate (NAA) and myo-inositol (MI), may indicate neurotoxicity associated with drug abuse. In this study, the authors explored differences in brain metabolites between abstinent methamphetamine (MA) abusers and healthy comparison subjects and the associations between metabolite concentrations and clinical characteristics. METHOD: Proton magnetic resonance spectroscopy (MRS) was performed on 30 abstinent MA abusers and 20 healthy comparison subjects. Two sets of MA user subgroups were defined depending on abstinence duration (greater or less than 6 months) or the total cumulative MA dose (greater or less than 100 g lifetime). NAA and other metabolites were measured in the frontal gray and white matter and compared between MA abuser groups and healthy comparison subjects. RESULTS: MI concentrations were higher for the MA abusers relative to healthy comparison subjects. NAA concentration was lower in frontal white matter of MA abusers with a 'large' cumulative dose relative to those with a 'small' cumulative dose and to healthy comparison subjects. Additionally, in MA abusers NAA concentrations in frontal white matter correlated inversely with the cumulative MA dose. In contrast, there was no significant difference in frontal gray matter NAA concentration among the three groups. However, frontal gray matter NAA concentrations for MA abusers correlated negatively with the total cumulative MA dose and positively with the duration of abstinence. There were no differences between the different MA user groups for MI. CONCLUSIONS: The current findings suggest that MA-induced metabolic alterations of frontal gray and white matter are dose-dependent, for primarily male subjects. Additionally, these findings potentially suggest that the MA-related abnormalities may, in part, recover with abstinence in gray matter, but not in the white matter regions.
ISSN
0376-8716 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17084995

http://hdl.handle.net/10371/23176
DOI
https://doi.org/10.1016/j.drugalcdep.2006.09.011
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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