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Tractography-guided statistics (TGIS) in diffusion tensor imaging for the detection of gender difference of fiber integrity in the midsagittal and parasagittal corpora callosa

Cited 44 time in Web of Science Cited 44 time in Scopus
Authors
Oh, Jungsu S.; Song, In Chan; Lee, Jae Sung; Kang, Hyejin; Park, Kwang Suk; Kang, Eunjoo; Lee, Dong Soo
Issue Date
2007
Publisher
Elsevier
Citation
NeuroImage 36, 606–616
Keywords
Diffusion tensor imaging (DTI)Fractional anisotropy (FA)Corpus callosum (CC)MidsagittalParasagittalTractography-guided statistics (TGIS)Parameterization
Abstract
Parasagittal or off-midsagittal structures of the interhemispheric fiber tracts, i.e., the corpus callosum (CC), have a tendency to form structures which diverge from the midsagittal CC (mCC). This has led to mild inconsistencies in terms of defining parasagittal structures as region of interest for diffusion tensor imaging (DTI) analysis. Moreover, it is a labor-intensive work with potential inconsistencies and inaccuracies to define the parasagittal structure slice by slice using currently available methods. In the present study, to better cope with these problems, a new method was developed to construct the extended parasagittal structure of the CC using diffusion tensor tractography-guided (TGI) parameterization methods based on tract-length-based and parasagittal plane-based extensions. Using extended ROIs, fractional anisotropy (FA) values, as the indicators of fiber integrity in DTI, were compared between normal 14 male (25.7+/-4.7 years) and 17 female (25.9+/-4.6 years) groups for investigating the gender difference. Both TGI parameterization methods showed that men have significantly higher regional FA values than women for global CC structure areas in parasagittal and midsagittal space. In contrast, women showed significantly higher FA values in the partial areas of the rostrum, genu and splenium. Our findings based on TGI statistics (TGIS) of fiber integrity could serve as a frame of reference for assessing the group differences of the CCs in finer scale and in more extended space or parasagittal space.
ISSN
1053-8119 (Print)
Language
English
URI
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WNP-4NC4M92-3&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=fbe7e5e239aad8be2467b96d03b3d989

http://hdl.handle.net/10371/23386
DOI
https://doi.org/10.1016/j.neuroimage.2007.03.020
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College of Medicine/School of Medicine (의과대학/대학원)Radiology (영상의학전공)Journal Papers (저널논문_영상의학전공)
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