S-Space College of Medicine/School of Medicine (의과대학/대학원) Psychiatry (정신과학전공) Journal Papers (저널논문_정신과학전공)
No association of the MCP-1 promoter A-2518G polymorphism with bipolar disorder in the Korean population
- Roh, Myoung-Sun; Lee, Kyu Young; Joo, Eun-Jeong; Lee, Namyoung; Kim, Yong Sik
- Issue Date
- Neurosci Lett. 42 7 (2007) 1-5
- Adult; Age of Onset; Bipolar Disorder/ethnology/*genetics/metabolism; Brain/metabolism/physiopathology; Brain Chemistry/*genetics; Case-Control Studies; Chemokine CCL2/*genetics; DNA Mutational Analysis; Female; Gene Frequency; Genetic Markers/genetics; Genetic Predisposition to Disease/*genetics; Genetic Screening; Genotype; Humans; Korea/ethnology; Male; Middle Aged; Polymorphism, Single Nucleotide/*genetics; Promoter Regions, Genetic/*genetics
- It has been suggested that bipolar disorder is associated with altered immune function. Monocyte chemoattractant protein-1 (MCP-1) is a chemokine that influences both neural and immune functions. We thus hypothesized that MCP-1 may be related to the development or pathophysiology of bipolar disorder. In this case-control study, we investigated the association between the A-2518G single nucleotide polymorphism (SNP) of the MCP-1 promoter and bipolar disorder. Patients with bipolar disorder (n=183; bipolar I=145, bipolar II=38) and healthy controls (350) were recruited for the study. No significant allelic or genotypic association was detected between the A-2518G polymorphism and any sample of bipolar disorder patients. When we pooled the healthy controls and the cases of bipolar I disorder from previous Korean studies and this study, we again found no significant association. No significant difference in either allele frequency or genotype distribution was observed between bipolar I and bipolar II disorders. There was no difference in the age at onset of bipolar disorder among the three genotype groups. Our data suggest that the A-2518G polymorphism of MCP-1 is not a major susceptibility factor for bipolar disorder in the Korean population. However, the physiological role of MCP-1 is highly suggestive of its being associated with bipolar disorder, and further analyses of other SNPs of MCP-1 remain to be performed.
- 0304-3940 (Print)
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