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No association of the MCP-1 promoter A-2518G polymorphism with bipolar disorder in the Korean population

Cited 11 time in Web of Science Cited 13 time in Scopus
Authors
Roh, Myoung-Sun; Lee, Kyu Young; Joo, Eun-Jeong; Lee, Namyoung; Kim, Yong Sik
Issue Date
2007
Publisher
Elsevier
Citation
Neurosci Lett. 42 7 (2007) 1-5
Keywords
AdultAge of OnsetBipolar Disorder/ethnology/*genetics/metabolismBrain/metabolism/physiopathologyBrain Chemistry/*geneticsCase-Control StudiesChemokine CCL2/*geneticsDNA Mutational AnalysisFemaleGene FrequencyGenetic Markers/geneticsGenetic Predisposition to Disease/*geneticsGenetic ScreeningGenotypeHumansKorea/ethnologyMaleMiddle AgedPolymorphism, Single Nucleotide/*geneticsPromoter Regions, Genetic/*genetics
Abstract
It has been suggested that bipolar disorder is associated with altered immune function. Monocyte chemoattractant protein-1 (MCP-1) is a chemokine that influences both neural and immune functions. We thus hypothesized that MCP-1 may be related to the development or pathophysiology of bipolar disorder. In this case-control study, we investigated the association between the A-2518G single nucleotide polymorphism (SNP) of the MCP-1 promoter and bipolar disorder. Patients with bipolar disorder (n=183; bipolar I=145, bipolar II=38) and healthy controls (350) were recruited for the study. No significant allelic or genotypic association was detected between the A-2518G polymorphism and any sample of bipolar disorder patients. When we pooled the healthy controls and the cases of bipolar I disorder from previous Korean studies and this study, we again found no significant association. No significant difference in either allele frequency or genotype distribution was observed between bipolar I and bipolar II disorders. There was no difference in the age at onset of bipolar disorder among the three genotype groups. Our data suggest that the A-2518G polymorphism of MCP-1 is not a major susceptibility factor for bipolar disorder in the Korean population. However, the physiological role of MCP-1 is highly suggestive of its being associated with bipolar disorder, and further analyses of other SNPs of MCP-1 remain to be performed.
ISSN
0304-3940 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17928143

http://hdl.handle.net/10371/23405
DOI
https://doi.org/10.1016/j.neulet.2007.04.038
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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