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No association of the MCP-1 promoter A-2518G polymorphism with bipolar disorder in the Korean population
DC Field | Value | Language |
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dc.contributor.author | Roh, Myoung-Sun | - |
dc.contributor.author | Lee, Kyu Young | - |
dc.contributor.author | Joo, Eun-Jeong | - |
dc.contributor.author | Lee, Namyoung | - |
dc.contributor.author | Kim, Yong Sik | - |
dc.date.accessioned | 2009-12-30T01:24:51Z | - |
dc.date.available | 2009-12-30T01:24:51Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Neurosci Lett. 42 7 (2007) 1-5 | en |
dc.identifier.issn | 0304-3940 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17928143 | - |
dc.identifier.uri | https://hdl.handle.net/10371/23405 | - |
dc.description.abstract | It has been suggested that bipolar disorder is associated with altered immune function. Monocyte chemoattractant protein-1 (MCP-1) is a chemokine that influences both neural and immune functions. We thus hypothesized that MCP-1 may be related to the development or pathophysiology of bipolar disorder. In this case-control study, we investigated the association between the A-2518G single nucleotide polymorphism (SNP) of the MCP-1 promoter and bipolar disorder. Patients with bipolar disorder (n=183; bipolar I=145, bipolar II=38) and healthy controls (350) were recruited for the study. No significant allelic or genotypic association was detected between the A-2518G polymorphism and any sample of bipolar disorder patients. When we pooled the healthy controls and the cases of bipolar I disorder from previous Korean studies and this study, we again found no significant association. No significant difference in either allele frequency or genotype distribution was observed between bipolar I and bipolar II disorders. There was no difference in the age at onset of bipolar disorder among the three genotype groups. Our data suggest that the A-2518G polymorphism of MCP-1 is not a major susceptibility factor for bipolar disorder in the Korean population. However, the physiological role of MCP-1 is highly suggestive of its being associated with bipolar disorder, and further analyses of other SNPs of MCP-1 remain to be performed. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Adult | en |
dc.subject | Age of Onset | en |
dc.subject | Bipolar Disorder/ethnology/*genetics/metabolism | en |
dc.subject | Brain/metabolism/physiopathology | en |
dc.subject | Brain Chemistry/*genetics | en |
dc.subject | Case-Control Studies | en |
dc.subject | Chemokine CCL2/*genetics | en |
dc.subject | DNA Mutational Analysis | en |
dc.subject | Female | en |
dc.subject | Gene Frequency | en |
dc.subject | Genetic Markers/genetics | en |
dc.subject | Genetic Predisposition to Disease/*genetics | en |
dc.subject | Genetic Screening | en |
dc.subject | Genotype | en |
dc.subject | Humans | en |
dc.subject | Korea/ethnology | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Polymorphism, Single Nucleotide/*genetics | en |
dc.subject | Promoter Regions, Genetic/*genetics | en |
dc.title | No association of the MCP-1 promoter A-2518G polymorphism with bipolar disorder in the Korean population | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 노명선 | - |
dc.contributor.AlternativeAuthor | 이규영 | - |
dc.contributor.AlternativeAuthor | 주은정 | - |
dc.contributor.AlternativeAuthor | 이남영 | - |
dc.contributor.AlternativeAuthor | 김용식 | - |
dc.identifier.doi | 10.1016/j.neulet.2007.04.038 | - |
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