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No association of the MCP-1 promoter A-2518G polymorphism with bipolar disorder in the Korean population

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dc.contributor.authorRoh, Myoung-Sun-
dc.contributor.authorLee, Kyu Young-
dc.contributor.authorJoo, Eun-Jeong-
dc.contributor.authorLee, Namyoung-
dc.contributor.authorKim, Yong Sik-
dc.date.accessioned2009-12-30T01:24:51Z-
dc.date.available2009-12-30T01:24:51Z-
dc.date.issued2007-
dc.identifier.citationNeurosci Lett. 42 7 (2007) 1-5en
dc.identifier.issn0304-3940 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17928143-
dc.identifier.urihttps://hdl.handle.net/10371/23405-
dc.description.abstractIt has been suggested that bipolar disorder is associated with altered immune function. Monocyte chemoattractant protein-1 (MCP-1) is a chemokine that influences both neural and immune functions. We thus hypothesized that MCP-1 may be related to the development or pathophysiology of bipolar disorder. In this case-control study, we investigated the association between the A-2518G single nucleotide polymorphism (SNP) of the MCP-1 promoter and bipolar disorder. Patients with bipolar disorder (n=183; bipolar I=145, bipolar II=38) and healthy controls (350) were recruited for the study. No significant allelic or genotypic association was detected between the A-2518G polymorphism and any sample of bipolar disorder patients. When we pooled the healthy controls and the cases of bipolar I disorder from previous Korean studies and this study, we again found no significant association. No significant difference in either allele frequency or genotype distribution was observed between bipolar I and bipolar II disorders. There was no difference in the age at onset of bipolar disorder among the three genotype groups. Our data suggest that the A-2518G polymorphism of MCP-1 is not a major susceptibility factor for bipolar disorder in the Korean population. However, the physiological role of MCP-1 is highly suggestive of its being associated with bipolar disorder, and further analyses of other SNPs of MCP-1 remain to be performed.en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectAdulten
dc.subjectAge of Onseten
dc.subjectBipolar Disorder/ethnology/*genetics/metabolismen
dc.subjectBrain/metabolism/physiopathologyen
dc.subjectBrain Chemistry/*geneticsen
dc.subjectCase-Control Studiesen
dc.subjectChemokine CCL2/*geneticsen
dc.subjectDNA Mutational Analysisen
dc.subjectFemaleen
dc.subjectGene Frequencyen
dc.subjectGenetic Markers/geneticsen
dc.subjectGenetic Predisposition to Disease/*geneticsen
dc.subjectGenetic Screeningen
dc.subjectGenotypeen
dc.subjectHumansen
dc.subjectKorea/ethnologyen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPolymorphism, Single Nucleotide/*geneticsen
dc.subjectPromoter Regions, Genetic/*geneticsen
dc.titleNo association of the MCP-1 promoter A-2518G polymorphism with bipolar disorder in the Korean populationen
dc.typeArticleen
dc.contributor.AlternativeAuthor노명선-
dc.contributor.AlternativeAuthor이규영-
dc.contributor.AlternativeAuthor주은정-
dc.contributor.AlternativeAuthor이남영-
dc.contributor.AlternativeAuthor김용식-
dc.identifier.doi10.1016/j.neulet.2007.04.038-
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