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Modafinil-induced hippocampal activation in narcolepsy

Cited 11 time in Web of Science Cited 14 time in Scopus
Authors
Kim, Yu Kyeong; Yoon, In-Young; Shin, Yoon-Kyung; Cho, Sang Soo; Kim, Sang Eun
Issue Date
2007-06-30
Publisher
Modafinil-induced hippocampal activation in narcolepsy
Citation
Neurosci Lett. 422 (2007) 91-96
Keywords
AdolescentAdultBenzhydryl Compounds/*pharmacology/therapeutic useBrain MappingBrain Stem/drug effects/metabolism/radionuclide imagingCentral Nervous System Stimulants/*pharmacology/therapeutic useEnergy Metabolism/drug effectsFemaleFluorodeoxyglucose F18/diagnostic useFunctional Laterality/drug effectsGlucose/metabolismHippocampus/*drug effects/*metabolism/radionuclide imagingHumansHypothalamus/drug effects/metabolism/radionuclide imagingMaleNarcolepsy/*drug therapy/*physiopathology/radionuclide imagingNeural Pathways/drug effects/metabolism/radionuclide imagingPositron-Emission TomographySleepThalamus/drug effects/metabolism/radionuclide imagingTreatment OutcomeWakefulness
Abstract
This study was undertaken to investigate regional metabolic abnormalities and to determine the effects of modafinil in narcoleptics on cerebral glucose metabolism using [(18)F] fluorodeoxyglucose positron emission tomography (FDG PET). Eight narcoleptic patients participated in the study. Two [(18)F] FDG PET scans were obtained before and after 2 weeks of modafinil treatment. To identify the effect of modafinil on regional cerebral abnormalities in narcoleptics, pre- and post-treatment PET scans were compared using paired t-statistics with voxel-wised manner. In narcolepsy patients, significant decreases in cerebral glucose metabolism were observed in the midbrain and upper pons, bilateral hypothalamus, posterior thalamus, hippocampus and right parahippocampus as compared with healthy subjects. After treatment, a significant increase in glucose metabolism in the left hippocampus was found in comparison with pre-treatment scan. This study demonstrated that modafinil activates the hippocampus which receives the afferents from hypothalamus, the center of sleep-wake rhythm.
ISSN
0304-3940 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17600622

http://hdl.handle.net/10371/23407
DOI
https://doi.org/10.1016/j.neulet.2007.04.085
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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