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Induction of transcription factor A-myb expression in reactive astrocytes following an excitotoxic lesion in the mouse hippocampus

Cited 2 time in Web of Science Cited 2 time in Scopus
Authors
Jeon, Gye Sun; Byun, Hee Jine; Park, Sung Kyung; Park, Sang Wook; Kim, Dong Woon; Seo, Je Hoon; Cha, Chong Ik; Cho, San Sun
Issue Date
2006-10-21
Publisher
Springer Verlag
Citation
Neurochem Res. 2006 Nov;31(11):1371-4. Epub 2006 Oct 20.
Keywords
AnimalsAstrocytes/drug effects/*metabolismBlotting, WesternDensitometryExcitatory Amino Acid Agonists/administration & dosage/*toxicityFluorescent Antibody TechniqueHippocampus/*pathologyImmunohistochemistryInjections, IntraventricularKainic Acid/administration & dosage/*toxicityMaleMiceMice, Inbred ICRProto-Oncogene Proteins/*biosynthesisSignal Transduction/drug effectsTrans-Activators/*biosynthesis
Abstract
In the present study, we examined patterns of A-myb expression in the kainic acid (KA)-treated mouse hippocampus. Western blot analysis revealed that A-myb expression was dramatically increased in brain 3 days after KA treatment, and was sustained for more than 7 days. A-myb immunoreactivity was restricted to hippocampal neurons in control mice. Three days after KA treatment, strong A-myb immunoreactivity was observed in reactive astrocytes throughout the CA3 region. Thereafter, A-myb immunoreactive astrocytes gradually concentrated around the CA3 region in parallel with selective neuronal loss, and only a few A-myb immunoreactive astrocytes persisted in the CA3 region 14 days after KA treatment. These findings suggest that the A-myb plays a role in the reactive gliosis signaling pathway in KA-induced excitotoxic lesions.
ISSN
0364-3190 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17053967

http://hdl.handle.net/10371/23911
DOI
https://doi.org/10.1007/s11064-006-9184-x
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College of Medicine/School of Medicine (의과대학/대학원)Anatomy (해부학전공)Journal Papers (저널논문_해부학전공)
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