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Subjective response to clozapine and risperidone treatment in outpatients with schizophrenia

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dc.contributor.authorKim, Jong-Hoon-
dc.contributor.authorKim, Seong-Youn-
dc.contributor.authorAhn, Yong Min-
dc.contributor.authorKim, Yong Sik-
dc.date.accessioned2009-12-31T02:11:01Z-
dc.date.available2009-12-31T02:11:01Z-
dc.date.issued2005-11-29-
dc.identifier.citationProg Neuropsychopharmacol Biol Psychiatry. 2006 Mar;30(2):301-5. Epub 2005 Nov 23.en
dc.identifier.issn0278-5846 (Print)-
dc.identifier.urihttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TBR-4HMNG91-3&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=29be707aa3bbad07cf021c3e25cc5338-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16309807-
dc.identifier.urihttp://hdl.handle.net/10371/24032-
dc.description.abstractThe purpose of the present study was to compare the subjective response and attitude towards antipsychotic treatment between schizophrenic patients receiving clozapine and those receiving risperidone. Ninety-four outpatients who had been on a stable drug dosage were evaluated (clozapine group: n=57, mean dose=254.1 mg/day; risperidone group: n=37, mean dose=3.0 mg/day). Subjective response to antipsychotic treatment was assessed using the Drug Attitude Inventory (DAI). The two treatment groups had a positive total mean score, indicating that both groups had a positive subjective view of drug treatment. The proportion of subjects who had a positive total score was not different between the two groups. In subscale scores, multivariate analysis revealed that clozapine group tended to have a higher score on the subjective positive response subscale (P=0.06). The scores of subjective negative response or attitude to medication subscales were not different between groups. In conclusion, there was no marked difference between stabilized outpatients taking clozapine and risperidone in terms of subjective response and attitude towards antipsychotic treatment. Considering that subjects treated with clozapine were treatment resistant patients, equal DAI score might indicate a more favorable subjective experience of clozapine. Further prospective studies on subjective response to various atypical agents are required to obtain valuable insight into how best to use these drugs from the patient's perspective.en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectAdulten
dc.subjectAntipsychotic Agents/*therapeutic useen
dc.subjectAttitudeen
dc.subjectChi-Square Distributionen
dc.subjectClozapine/*therapeutic useen
dc.subjectDrug Therapy, Combinationen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMultivariate Analysisen
dc.subjectOutpatients/*psychologyen
dc.subjectPsychiatric Status Rating Scalesen
dc.subjectQuestionnairesen
dc.subjectRisperidone/*therapeutic useen
dc.subjectSchizophrenia/*drug therapyen
dc.subject*Schizophrenic Psychologyen
dc.subjectTime Factorsen
dc.titleSubjective response to clozapine and risperidone treatment in outpatients with schizophreniaen
dc.typeArticleen
dc.contributor.AlternativeAuthor김종훈-
dc.contributor.AlternativeAuthor김승윤-
dc.contributor.AlternativeAuthor안용민-
dc.contributor.AlternativeAuthor김용식-
dc.identifier.doi10.1016/j.pnpbp.2005.10.006-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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