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Role of NKT cells in allogeneic islet graft survival
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, Seung Hee | - |
dc.contributor.author | Jin, Ji Zhe | - |
dc.contributor.author | Lee, Se Han | - |
dc.contributor.author | Park, Hyungbae | - |
dc.contributor.author | Kim, Chi Hwa | - |
dc.contributor.author | Lee, Dong-Sup | - |
dc.contributor.author | Kim, Suhnggwon | - |
dc.contributor.author | Chung, Nam Hyun | - |
dc.contributor.author | Kim, Yon Su | - |
dc.date.accessioned | 2009-12-31T02:34:55Z | - |
dc.date.available | 2009-12-31T02:34:55Z | - |
dc.date.issued | 2007-07-31 | - |
dc.identifier.citation | Clin Immunol. 2007 Sep;124(3):258-66. Epub 2007 Jul 26. | en |
dc.identifier.issn | 1521-6616 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17662658 | - |
dc.identifier.uri | https://hdl.handle.net/10371/24100 | - |
dc.description.abstract | Although NKT cells expressing CD1d-reactive TCR exerted protective role in autoimmune diseases, the regulatory function of CD1d-dependent NKT cells in alloimmune responses has not been investigated thoroughly. Here, we demonstrated the regulatory effects of NKT cells using a pancreas islet transplantation model. CD40/CD154 blocking induced long-term graft survival in most B6 recipients, but B6.CD1d(-/-) recipients showed co-stimulation blockade-resistant rejection. Adoptive transfer of NKT cells into B6.CD1d(-/-) restored tolerizing capacity of co-stimulatory blockade. Activation of NKT cells was effective for the prolongation of graft survival and up-regulated membrane-bound TGF-beta expression transiently on their cell surface. The activated CD1d-dependent NKT cells inhibited alloantigen-driven cell proliferation through cell contacts and the beneficial effect of CD154 blocking for allograft survival was related to TGF-beta pathway. Thus, we can conclude that NKT cells are essential for the stable allograft survival and the regulatory function is dependent on, at least in part, TGF-beta engagement. | en |
dc.language.iso | en | - |
dc.publisher | Elsevier | en |
dc.subject | Animals | en |
dc.subject | Antigens, CD1/genetics/*metabolism | en |
dc.subject | Antigens, CD1d | en |
dc.subject | Graft Survival/*immunology | en |
dc.subject | Histocompatibility Antigens Class II/metabolism | en |
dc.subject | Islets of Langerhans Transplantation/*immunology | en |
dc.subject | Killer Cells, Natural/*immunology | en |
dc.subject | Male | en |
dc.subject | Mice | en |
dc.subject | Mice, Inbred C57BL | en |
dc.subject | Mice, Knockout | en |
dc.subject | Time Factors | en |
dc.subject | Transforming Growth Factor beta/metabolism | en |
dc.subject | Transplantation Tolerance/immunology | en |
dc.subject | Up-Regulation | en |
dc.title | Role of NKT cells in allogeneic islet graft survival | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 양승희 | - |
dc.contributor.AlternativeAuthor | 이세한 | - |
dc.contributor.AlternativeAuthor | 박형배 | - |
dc.contributor.AlternativeAuthor | 김치화 | - |
dc.contributor.AlternativeAuthor | 이동섭 | - |
dc.contributor.AlternativeAuthor | 김성곤 | - |
dc.contributor.AlternativeAuthor | 정남현 | - |
dc.contributor.AlternativeAuthor | 김연수 | - |
dc.identifier.doi | 10.1016/j.clim.2007.06.003 | - |
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