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Melatonin protects against neuronal damage induced by 3-nitropropionic acid in rat striatum

Cited 50 time in Web of Science Cited 57 time in Scopus
Authors
Nam, Eunjoo; Lee, Seung Min; Koh, Seong Eun; Joo, Wan Seok; Maeng, Sungho; Im, Heh In; Kim, Yong Sik
Issue Date
2005-05-11
Publisher
Elsevier
Citation
Brain Res. 2005 Jun 7;1046(1-2):90-6.
Keywords
Analysis of VarianceAnimalsAntioxidants/pharmacologyCell Death/drug effectsCorpus Striatum/*drug effects/pathologyLipid Peroxidation/drug effectsMaleMelatonin/*pharmacologyMotor SkillsNerve Degeneration/chemically inducedNeuroprotective Agents/*pharmacologyNeurons/*drug effects/*pathologyNeurotoxinsNitro CompoundsOxidative Stress/drug effectsPropionic AcidsRatsRats, Sprague-DawleyRotarod Performance Test
Abstract
In this study, the protective effects of melatonin were evaluated against 3-nitropropionic acid (3-NP)-induced striatal neuronal damage in rats. Lesions were induced in the right striatum of Sprague-Dawley rats by stereotaxic injection with 3-NP and melatonin was intraperitoneally administered both 30 min before and 60 min after 3-NP injection. And rats continuously received melatonin daily for 3 days. As indicators of oxidative damage, lipid peroxidation and protein oxidation in the lesioned striatum were measured at 1 day after 3-NP injection. Levels of malondialdehyde (MDA) and protein carbonyl were significantly increased by 3-NP injection, but reduced in the melatonin-treated rats. Four days post-lesion, large lesions and extensive neuronal damage were produced in the 3-NP-injected striata, as revealed by 2,3,5-triphenyltetrazolium chloride (TTC) staining. In addition, marked ipsilateral rotational behavior following apomorphine challenge and a decrease of dopamine content in the lesioned striatum were observed in the 3-NP-injected rats. However, melatonin treatment significantly attenuated the 3-NP-induced neuronal damage, reduced the degree of asymmetric rotational behavior, and restored the dopamine level in the lesioned striatum. The present results indicate that melatonin effectively protects against the neuronal damage caused by 3-NP in vivo and that the neuroprotective effects of melatonin may be related to antioxidant action.
ISSN
0006-8993 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15882841

http://hdl.handle.net/10371/24398
DOI
https://doi.org/10.1016/j.brainres.2005.03.053
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College of Medicine/School of Medicine (의과대학/대학원)Pharmacology (약리학전공)Journal Papers (저널논문_약리학전공)
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