S-Space College of Medicine/School of Medicine (의과대학/대학원) Anatomy (해부학전공) Journal Papers (저널논문_해부학전공)
Immunohistochemical localization of sodium-dependent L-ascorbic acid transporter 1 protein in rat kidney
- Lee, Ju Hyun; Oh, Chang Seok; Mun, Ga Hee; Kim, Jae hyup; Chung, Yoon Hee; Hwang, Young Il; Shin, Dong Hoon; Lee, Wang Jae
- Issue Date
- Springer Verlag
- Histochem Cell Biol. 2006 Oct;126(4):491-4. Epub 2006 May 4.
- Animals; Immunohistochemistry; Kidney/*chemistry; Organic Anion Transporters, Sodium-Dependent/*analysis; Rats; Symporters/*analysis
- Recently, two L-ascorbic acid transporters were identified; sodium-dependent vitamin C transporter (SVCT) 1 and SVCT2. The previous study suggested that SVCT protein might be present on the apical membrane in the straight segment (S3) of proximal tubule. In the present study, SVCT1 immunoreactivity (IR) was observed in the brush border of proximal straight tubules in the medullary ray of renal cortex and the outer stripe of outer medulla, while SVCT2 IR was not localized in any region of the kidney. Since the mechanism of VC reabsorption in the kidney has not been fully elucidated up to the present time, it is meaningful to demonstrate the exact cellular distribution of SVCT protein in the kidney.
- 0948-6143 (Print)
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