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Immunohistochemical localization of sodium-dependent L-ascorbic acid transporter 1 protein in rat kidney

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Authors
Lee, Ju Hyun; Oh, Chang Seok; Mun, Ga Hee; Kim, Jae hyup; Chung, Yoon Hee; Hwang, Young Il; Shin, Dong Hoon; Lee, Wang Jae
Issue Date
2006-05-05
Publisher
Springer Verlag
Citation
Histochem Cell Biol. 2006 Oct;126(4):491-4. Epub 2006 May 4.
Keywords
AnimalsImmunohistochemistryKidney/*chemistryOrganic Anion Transporters, Sodium-Dependent/*analysisRatsSymporters/*analysis
Abstract
Recently, two L-ascorbic acid transporters were identified; sodium-dependent vitamin C transporter (SVCT) 1 and SVCT2. The previous study suggested that SVCT protein might be present on the apical membrane in the straight segment (S3) of proximal tubule. In the present study, SVCT1 immunoreactivity (IR) was observed in the brush border of proximal straight tubules in the medullary ray of renal cortex and the outer stripe of outer medulla, while SVCT2 IR was not localized in any region of the kidney. Since the mechanism of VC reabsorption in the kidney has not been fully elucidated up to the present time, it is meaningful to demonstrate the exact cellular distribution of SVCT protein in the kidney.
ISSN
0948-6143 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16673096

http://hdl.handle.net/10371/24431
DOI
https://doi.org/10.1007/s00418-006-0186-1
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College of Medicine/School of Medicine (의과대학/대학원)Anatomy (해부학전공)Journal Papers (저널논문_해부학전공)
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