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Decreased GABA levels in anterior cingulate and basal ganglia in medicated subjects with panic disorder: a proton magnetic resonance spectroscopy (1H-MRS) study

Cited 45 time in Web of Science Cited 46 time in Scopus
Authors
Ham, Byung-Joo; Sung, Younghoon; Kim, Namkug; Kim, Seog Ju; Kim, Jieun E; Kim, Dajung J; Lee, Jeeyoung Y; Kim, Jihyun H; Yoon, Sujung J; Lyoo, In Kyoon
Issue Date
2006-12-05
Publisher
Elsevier
Citation
Prog Neuropsychopharmacol Biol Psychiatry. 2007 Mar 30;31(2):403-11. Epub 2006 Dec 1.
Keywords
AdultBasal Ganglia/*metabolismCase-Control StudiesCholine/metabolismFemaleGyrus Cinguli/*metabolismHumansLactic Acid/metabolismMagnetic Resonance Imaging/methodsMagnetic Resonance Spectroscopy/*methodsMalePanic Disorder/*metabolism/*pathologyProtonsgamma-Aminobutyric Acid/*metabolism
Abstract
The purpose of this study was to investigate the brain gamma-aminobutyric acid (GABA) concentration and its relationship with clinical variables in patients with panic disorder (PD). Single voxel proton magnetic resonance spectroscopy ((1)H-MRS) scan was performed on 22 medicated subjects with PD and 25 age and sex-matched healthy comparison subjects. GABA and other metabolite levels were measured in the anterior cingulate cortex (ACC) and basal ganglia. GABA levels were significantly lower in the ACC and basal ganglia of PD patients relative to comparison subjects. Lactate and choline concentrations in the ACC in PD patients were also higher than in the comparison subjects. Our data suggested in part that alterations of the GABA function and the energy metabolism in ACC and basal ganglia may play an important role in the pathophysiology of panic disorder.
ISSN
0278-5846 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17141385

http://hdl.handle.net/10371/24512
DOI
https://doi.org/10.1016/j.pnpbp.2006.10.011
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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