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Hippocampal shape deformity analysis in obsessive-compulsive disorder

Cited 25 time in Web of Science Cited 24 time in Scopus
Authors
Hong, Soon Beom; Shin, Yong-Wook; Kim, Sun Hyung; Yoo, So Young; Lee, Jong-Min; Kim, In Young; Kim, Sun I; Kwon, Jun Soo
Issue Date
2007-04-28
Publisher
Springer Verlag
Citation
Eur Arch Psychiatry Clin Neurosci. 2007 Jun;257(4):185-90. Epub 2007 Apr 26.
Keywords
AdultFemaleFunctional Laterality/physiologyHippocampus/*pathologyHumansImage Processing, Computer-AssistedMaleModels, NeurologicalObsessive-Compulsive Disorder/*pathology
Abstract
Abnormalities of orbital prefrontal cortex and caudate nuclei have, thus far, been the main findings regarding the pathophysiology of obsessive-compulsive disorder (OCD). On the other hand, neuroimaging studies have failed to reach a consensus with regard to the issue of hippocampal abnormalities in OCD patients. Shape analysis may facilitate a resolution of the discordance among these former studies by detecting local structural changes, thus enhancing power to discriminate structural differences. It has been suggested that neural circuitry interconnecting brain areas may critically influence the shape of neuroanatomical structures, serving as a rationale for better sensitivity of shape analysis compared to volume analysis, especially in detecting abnormalities of neural circuitry. Shape analysis of the hippocampus was performed in 22 matched pairs of OCD patients and normal control subjects. As a result, we observed a bilateral hippocampal shape deformity including the most prominent characteristic of downward displacement of the head. The hippocampal structural alteration observed in this study indicates that this structure may play a role in the pathophysiology of OCD. Also, further considering the hippocampal neural connections specific to its surface topography, these surface deformities may reflect developmental alterations in these patients with regard to the neural circuitry involving hippocampus.
ISSN
0940-1334 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17464548

http://hdl.handle.net/10371/24525
DOI
https://doi.org/10.1007/s00406-006-0655-5
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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