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Family-based association study between GRIK2 polymorphisms and autism spectrum disorders in the Korean trios
Cited 32 time in
Web of Science
Cited 37 time in Scopus
- Authors
- Issue Date
- 2007-04-13
- Publisher
- Elsevier
- Citation
- Neurosci Res. 2007 Jul;58(3):332-5. Epub 2007 Mar 13.
- Keywords
- Adolescent ; Autistic Disorder/epidemiology/*genetics ; Child ; Child, Preschool ; Female ; Gene Frequency ; Genotype ; Humans ; Korea/epidemiology ; Linkage Disequilibrium ; Male ; Polymorphism, Single Nucleotide/*genetics ; Receptors, Kainic Acid/*genetics ; Family Health
- Abstract
- Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with strong genetic components. The present study comprises the detection of four single nucleotide polymorphisms (SNPs) in GRIK2 followed by a family-based association analysis of the SNPs in 126 Korean ASD trios by using the transmission disequilibrium test (TDT) and haplotype analysis. We found preferential transmission of the C allele at the rs3213607 (P<0.001) of GRIK2 in ASD and haplotype analysis revealed that one haplotype demonstrated a significant association (P=0.023). These results suggest a potential association between GRIK2 and ASD in the Korean population.
- ISSN
- 0168-0102 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17428563
https://hdl.handle.net/10371/24539
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