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White matter abnormalities in drug-naive patients with obsessive-compulsive disorder: a diffusion tensor study before and after citalopram treatment

Cited 112 time in Web of Science Cited 118 time in Scopus
Authors
Yoo, S Y; Jang, J H; Shin, Y-W; Kim, D J; Park, H-J; Moon, W-J; Chung, E C; Lee, J-M; Kim, I Y; Kim, S I; Kwon, J S
Issue Date
2007-07-28
Publisher
Wiley-Blackwell
Citation
Acta Psychiatr Scand. 2007 Sep;116(3):211-9.
Keywords
AdultAnisotropyAntidepressive Agents, Second-Generation/adverse effects/*therapeutic useBrain/*drug effectsCaudate Nucleus/drug effects/pathologyCerebral Cortex/drug effects/pathologyCitalopram/adverse effects/*therapeutic useCorpus Callosum/drug effects/pathology*Diffusion Magnetic Resonance ImagingDominance, Cerebral/physiologyFemaleFourier AnalysisHumans*Image Processing, Computer-AssistedInternal Capsule/drug effects/pathology*Magnetic Resonance ImagingMaleNerve Fibers, Myelinated/*drug effects/pathologyObsessive-Compulsive Disorder/diagnosis/*drug therapyThalamus/drug effects/pathology
Abstract
OBJECTIVE: The aim was to investigate the white matter abnormalities of drug-naive patients with obsessive-compulsive disorder (OCD) using diffusion tensor-imaging and the white matter changes in the patients after pharmacotherapy. METHOD: Thirteen drug-naive OCD patients and 13 age- and sex-matched healthy comparison subjects were examined using diffusion tensor-imaging and structural magnetic resonance imaging. Measurements were made in OCD patients before and after 12 weeks of citalopram treatment. RESULTS: Compared with controls, the drug-naive OCD patients showed significant increases in fractional anisotropy (FA) in the corpus callosum, the internal capsule and white matter in the area superolateral to the right caudate. The increases in FA were mostly no longer observed in patients after 12 weeks of treatment compared with controls. CONCLUSION: Our findings suggest that white matter alterations are associated with the pathophysiology of OCD, and the abnormalities may be partly reversible with pharmacotherapy.
ISSN
0001-690X (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17655563

http://hdl.handle.net/10371/24676
DOI
https://doi.org/10.1111/j.1600-0447.2007.01046.x
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College of Medicine/School of Medicine (의과대학/대학원)Program in Clinical Pharmacology (협동과정-임상약리학전공)Journal Papers (저널논문_협동과정-임상약리학전공)
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