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Decreased cerebral blood flow of the right anterior cingulate cortex in long-term and short-term abstinent methamphetamine users

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Authors
Hwang, Jaeuk; Lyoo, In Kyoon; Kim, Seog Ju; Sung, Young Hoon; Bae, Soojeong; Cho, Sung-Nam; Lee, Ho Young; Lee, Dong Soo; Renshaw, Perry F
Issue Date
2005-10-29
Publisher
Elsevier
Citation
Drug Alcohol Depend. 2006 Apr 28;82(2):177-81. Epub 2005 Oct 25.
Keywords
AdultAlcohol Drinking/physiopathologyCerebrovascular Circulation/*physiologyFemaleFunctional LateralityGyrus Cinguli/*blood supplyHumansMale*MethamphetamineReference ValuesSubstance-Related Disorders/*physiopathology/radionuclideimaging/rehabilitationTomography, Emission-Computed, Single-Photon
Abstract
BACKGROUND: The aim of the current study was to explore changes of relative regional cerebral blood flow (rCBF) in short-term and long-term abstinent methamphetamine (MA) users. METHODS: Relative rCBF in 40 abstinent MA users and 23 healthy comparison subjects was compared by the technetium-99m-hexamethyl-propylene amine oxime ((99m)Tc-HMPAO) single photon emission computed tomography (SPECT). Relative rCBF in areas that were found to differ significantly was also compared in groups of MA users with short-term (<6 months) and long-term (>or=6 months) abstinence. RESULTS: MA users showed decreased relative rCBF in the right anterior cingulate cortex (Brodmann area 32) relative to healthy comparison subjects. Long-term abstinent MA users had significantly greater rCBF than short-term abstinent MA users. CONCLUSIONS: We report that abstinent MA users have decreased rCBF in the anterior cingulate cortex with smaller relative decreases in subjects with prolonged abstinence.
ISSN
0376-8716 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16253441

http://hdl.handle.net/10371/24681
DOI
https://doi.org/10.1016/j.drugalcdep.2005.09.011
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College of Medicine/School of Medicine (의과대학/대학원)Nuclear Medicine (핵의학전공)Journal Papers (저널논문_핵의학전공)
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