S-Space College of Medicine/School of Medicine (의과대학/대학원) Nuclear Medicine (핵의학전공) Journal Papers (저널논문_핵의학전공)
Decreased cerebral blood flow of the right anterior cingulate cortex in long-term and short-term abstinent methamphetamine users
- Hwang, Jaeuk; Lyoo, In Kyoon; Kim, Seog Ju; Sung, Young Hoon; Bae, Soojeong; Cho, Sung-Nam; Lee, Ho Young; Lee, Dong Soo; Renshaw, Perry F
- Issue Date
- Drug Alcohol Depend. 2006 Apr 28;82(2):177-81. Epub 2005 Oct 25.
- Adult; Alcohol Drinking/physiopathology; Cerebrovascular Circulation/*physiology; Female; Functional Laterality; Gyrus Cinguli/*blood supply; Humans; Male; *Methamphetamine; Reference Values; Substance-Related Disorders/*physiopathology/radionuclide; imaging/rehabilitation; Tomography, Emission-Computed, Single-Photon
- BACKGROUND: The aim of the current study was to explore changes of relative regional cerebral blood flow (rCBF) in short-term and long-term abstinent methamphetamine (MA) users. METHODS: Relative rCBF in 40 abstinent MA users and 23 healthy comparison subjects was compared by the technetium-99m-hexamethyl-propylene amine oxime ((99m)Tc-HMPAO) single photon emission computed tomography (SPECT). Relative rCBF in areas that were found to differ significantly was also compared in groups of MA users with short-term (<6 months) and long-term (>or=6 months) abstinence. RESULTS: MA users showed decreased relative rCBF in the right anterior cingulate cortex (Brodmann area 32) relative to healthy comparison subjects. Long-term abstinent MA users had significantly greater rCBF than short-term abstinent MA users. CONCLUSIONS: We report that abstinent MA users have decreased rCBF in the anterior cingulate cortex with smaller relative decreases in subjects with prolonged abstinence.
- 0376-8716 (Print)
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