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Worldwide variation of dialysis-associated peritonitis in children

Cited 42 time in Web of Science Cited 54 time in Scopus
Authors
Schaefer, F; Feneberg, R; Aksu, N; Donmez, O; Sadikoglu, B; Alexander, S R; Mir, S; Ha, I S; Fischbach, M; Simkova, E; Watson, A R; Moller, K; von Baum, H; Warady, B A
Issue Date
2007
Publisher
Nature Publishing Group
Citation
Kidney Int 2007; 72: 1374-1379
Keywords
AdolescentAnti-Bacterial Agents/*therapeutic useArgentinaAsiaChildChild, PreschoolDrug Resistance, BacterialEuropeGram-Negative Bacterial Infections/drug therapy/etiologyGram-Positive Bacterial Infections/drug therapy/etiologyHumansIncidenceInfantInfant, NewbornInternational CooperationMexicoPeritoneal Dialysis/*adverse effectsPeritonitis/*drug therapy/*etiology/microbiology*Practice Guidelines as TopicProspective StudiesRegistries/*statistics & numerical dataTreatment OutcomeTurkeyUnited States
Abstract
Peritonitis is the most common cause of dialysis failure in children on chronic peritoneal dialysis. We performed a prospective study of 501 peritonitis episodes in 44 pediatric dialysis centers located in 14 countries that examined peritonitis etiology, efficiency of opinion-based management guidelines, and final outcomes. Culture-negative incidence varied significantly from 11% in North America to 67% in Mexico. Argentina and North America had the highest rate of Gram-negative episodes. Pseudomonas-based peritonitis was eightfold more common in the United States than in Europe, and correlated with the frequency of exit site cleansing and topical mupirocin administration. Significant regional variation in antibiotic susceptibility was noted for the first generation cephalosporins and aminoglycosides. Initial response rates to standardized empiric antibiotic treatment did not differ between regions; however, final outcomes were significantly less favorable in Eastern Europe. The wide regional variation in culture-negative peritonitis, and the distribution and antibiotic susceptibilities of causative bacteria needs to be taken into consideration when the guidelines for empiric therapy of pediatric dialysis-associated peritonitis are revised.
ISSN
0085-2538 (Print)
Language
English
URI
http://www.nature.com/ki/journal/v72/n11/abs/5002523a.html

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17882152

http://hdl.handle.net/10371/24802
DOI
https://doi.org/10.1038/sj.ki.5002523
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College of Medicine/School of Medicine (의과대학/대학원)Pediatrics (소아과학전공)Journal Papers (저널논문_소아과학전공)
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