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Involvement of E-selectin in recruitment of endothelial progenitor cells and angiogenesis in ischemic muscle
DC Field | Value | Language |
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dc.contributor.author | Oh, Il-Young | - |
dc.contributor.author | Yoon, Chang-Hwan | - |
dc.contributor.author | Hur, Jin | - |
dc.contributor.author | Kim, Ji-Hyun | - |
dc.contributor.author | Kim, Tae-Youn | - |
dc.contributor.author | Lee, Choon-Soo | - |
dc.contributor.author | Park, Kyung-Woo | - |
dc.contributor.author | Chae, In-Ho | - |
dc.contributor.author | Oh, Byung-Hee | - |
dc.contributor.author | Park, Young-Bae | - |
dc.contributor.author | Kim, Hyo-Soo | - |
dc.date.accessioned | 2010-01-04T05:49:21Z | - |
dc.date.available | 2010-01-04T05:49:21Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Blood. 2007;110:3891-3899 | en |
dc.identifier.issn | 0006-4971 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17699745 | - |
dc.identifier.uri | https://hdl.handle.net/10371/24890 | - |
dc.description.abstract | E-selectin plays critical roles in tethering leukocytes to endothelial cells (ECs). We studied the role of E-selectin in endothelial progenitor cell (EPC) homing and vasculogenesis. After ischemia, the expression of E-selectin on ECs peaked 6 to 12 hours and returned to baseline at 24 hours, whereas the level of soluble E-selectin (sE-selectin) in serum increased over 24 hours and remained high at day 7. Mouse bone marrow-derived EPCs expressed not only E-selectin but also its ligand. Homing of circulating EPCs to ischemic limb was significantly impaired in E-selectin knock-out mice, as well as wild-type mice pretreated with blocking antibody against E-selectin, which was rescued by local sE-selectin injection. Mechanism for this is that sE-selectin stimulated not only ECs to express ICAM-1, but also EPCs to secrete interleukin-8 (IL-8), leading to enhanced migration and incorporation to ECs capillary formation. In therapeutic aspect, local treatment with sE-selectin enhanced efficacy of EPC transplantation for vasculogenesis and salvage of ischemic limb. Conversely, when E-selectin was knocked down by E-selectin small interfering RNA, blood flow recovery after EPC transplantation was significantly impaired. But this impaired vasculogenesis was rescued by sE-selectin. In conclusion, these data demonstrate E-selectin is a pivotal molecule for EPCs' homing to ischemic limb and vasculogenesis. | en |
dc.language.iso | en | - |
dc.publisher | American Society of Hematology | en |
dc.subject | Animals | en |
dc.subject | E-Selectin/genetics/*metabolism/pharmacology | en |
dc.subject | Endothelial Cells/*metabolism/pathology | en |
dc.subject | Hindlimb/blood supply/metabolism/pathology | en |
dc.subject | Interleukin-8/biosynthesis | en |
dc.subject | Ischemia/drug therapy/genetics/*metabolism | en |
dc.subject | Mice | en |
dc.subject | Mice, Knockout | en |
dc.subject | Muscle, Skeletal/blood supply/*metabolism/pathology | en |
dc.subject | Neovascularization, Pathologic/drug therapy/genetics/*metabolism | en |
dc.subject | RNA, Small Interfering/genetics/pharmacology | en |
dc.subject | Stem Cell Transplantation | en |
dc.subject | Stem Cells | en |
dc.subject | Time Factors | en |
dc.subject | Transplantation, Homologous | en |
dc.subject | Cell Movement | - |
dc.title | Involvement of E-selectin in recruitment of endothelial progenitor cells and angiogenesis in ischemic muscle | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 오일영 | - |
dc.contributor.AlternativeAuthor | 윤창환 | - |
dc.contributor.AlternativeAuthor | 허진 | - |
dc.contributor.AlternativeAuthor | 김지현 | - |
dc.contributor.AlternativeAuthor | 김태윤 | - |
dc.contributor.AlternativeAuthor | 이춘수 | - |
dc.contributor.AlternativeAuthor | 박경우 | - |
dc.contributor.AlternativeAuthor | 채인호 | - |
dc.contributor.AlternativeAuthor | 오병희 | - |
dc.contributor.AlternativeAuthor | 박영배 | - |
dc.contributor.AlternativeAuthor | 김효수 | - |
dc.identifier.doi | 10.1182/blood-2006-10-048991 | - |
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