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Cortical thinning in obsessive compulsive disorder

Cited 40 time in Web of Science Cited 43 time in Scopus
Authors
Shin, Yong-Wook; Yoo, So Young; Lee, Jun Ki; Ha, Tae Hyon; Lee, Kyung Jin; Lee, Jong Min; Kim, In Young; Kim, Sun I; Kwon, Jun Soo
Issue Date
2007-05-26
Publisher
Wiley-Blackwell
Citation
Hum Brain Mapp 28:1128-1135
Keywords
AdultAtrophy/etiology/*pathology/physiopathologyBrain MappingCerebral Cortex/*pathology/physiopathologyFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleNeurodegenerative Diseases/*pathology/physiopathologyObsessive-Compulsive Disorder/*pathology/physiopathologyPredictive Value of TestsPrefrontal Cortex/pathology/physiopathologyTemporal Lobe/pathology/physiopathology
Abstract
Although studies of obsessive-compulsive disorder (OCD) over the last 20 years have suggested abnormalities in frontal-subcortical circuitry, evidences of structural abnormalities in those areas are still imperfect and contradictory. With recent advances in neuroimaging technology, it is now possible to study cortical thickness based on cortical surfaces, which offers a direct quantitative index of cortical mass. Using the constrained Laplacian-based automated segmentation with proximities (CLASP) algorithm, we measured cortical thickness of 55 patients with OCD (33 men and 22 women) and 52 age- and sex-matched healthy volunteers (32 men and 20 women). We found multiple regions of cortical thinning in OCD patients compared to the normal control group. Patients with OCD had thinner left inferior frontal, left middle frontal, left precentral, left superior temporal, left parahippocampal, left orbitofrontal, and left lingual cortices. Most thinned regions were located in the left ventral cortex system, providing a new perspective that this ventral cortical system may be involved in the pathophysiology of OCD.
ISSN
1065-9471 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17525985

http://hdl.handle.net/10371/24910
DOI
https://doi.org/10.1002/hbm.20338
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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