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Infrared exposure induces an angiogenic switch in human skin that is partially mediated by heat

Cited 47 time in Web of Science Cited 54 time in Scopus
Authors

Kim, M-S; Kim, Y K; Cho, K H; Chung, J H

Issue Date
2006-11-17
Publisher
Wiley-Blackwell
Citation
Br J Dermatol. 2006;155(6):1131-1138
Keywords
AdultBiopsyBlotting, NorthernDown-Regulation/radiation effectsEpidermis/metabolism/pathology/radiation effectsHumansInfrared Rays/*adverse effectsMaleNeovascularization, Pathologic/etiology/*physiopathologyReverse Transcriptase Polymerase Chain ReactionSkin/blood supply/metabolism/*radiation effectsSkin Temperature/radiation effectsThrombospondins/*biosynthesisUp-Regulation/radiation effectsVascular Endothelial Growth Factor A/*biosynthesis
Abstract
BACKGROUND: Angiogenesis plays an important role in physiological and pathological conditions of the skin. Although acute ultraviolet-induced skin angiogenesis has been investigated, little is known about the distinct effects of acute infrared (IR) radiation on angiogenesis in human skin. OBJECTIVES: To elucidate the molecular regulation of the angiogenic switch by acute near-IR radiation or by a single heat treatment in human skin in vivo. METHODS: We subjected 16 healthy volunteers to near-IR irradiation (six minimal heating doses) and 14 healthy volunteers to heat treatment (43 degrees C for 90 min), and skin specimens were obtained by punch biopsy for immunohistochemical, Western blot and reverse transcription-polymerase chain reaction analyses. RESULTS: We observed that CD31-stained vessels in the upper dermis were increased after acute near-IR exposure, and that this was associated with the upregulation of vascular endothelial growth factor (VEGF) and the downregulation of thrombospondin (TSP)-2. During the application of near-IR to buttock skin, skin temperatures immediately increased from 32 degrees C up to 42 degrees C, as measured using a digital thermometer. Moreover, the expression of inducible heat shock protein 70 was increased after near-IR irradiation in human skin. Therefore, we investigated the effects of a single heat treatment on angiogenesis and on the expression of VEGF and TSP-2 in skin, and found that vascularization and VEGF expression were increased, whereas TSP-2 expression was reduced. CONCLUSIONS: Our results suggest that IR radiation plays an important role in skin angiogenesis via regulation of the balance between the angiogenic inducer VEGF and the angiogenic inhibitor TSP-2, and that IR-induced skin angiogenesis might be partially caused by the effects of heat in human skin in vivo.
ISSN
0007-0963 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17107379

https://hdl.handle.net/10371/25662
DOI
https://doi.org/10.1111/j.1365-2133.2006.07510.x
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