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Development of acetylated HDD kit for preparation of 188Re-HDD/lipiodol

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Authors
Lee, Yun-Sang; Jeong, Jae Min; Kim, Young Joo; Chang, Young Soo; Lee, Hak Jeong; Son, Miwon; Lee, Jung Woo; Yoon, Heung Sik; Kang, Won Jun; Lee, Dong Soo; Chung, June-Key; Lee, Myung Chul; Suh, Young-Ger
Issue Date
2006-10-03
Publisher
Elsevier
Citation
Appl Radiat Isot. 2007 Jan;65(1):64-9. Epub 2006 Sep 28.
Keywords
AcetylationAnimalsEquipment DesignEquipment Failure AnalysisIodized Oil/*chemical synthesis/diagnosticuse/*pharmacokinetics/therapeutic useIsotope Labeling/*instrumentation/methodsMetabolic Clearance RateMiceOrgan SpecificityOrganometallic Compounds/*chemical synthesis/diagnosticuse/*pharmacokinetics/therapeutic useRadiopharmaceuticals/chemical synthesis/diagnosticuse/pharmacokinetics/therapeutic use*Reagent Kits, DiagnosticTissue Distribution
Abstract
A lipiodol solution of (188)Re-4-hexadecyl-2,2,9,9-tetramethyl-4,7-diaza-1,10-decanedithiol ((188)Re-HDD/lipiodol) is in clinical study for liver cancer therapy. However, formulation of it is difficult due to highly active and unstable sulfhydryl groups. We produced new kits using diacetylated HDD (AHDD), in which sulfhydryl groups are protected. We found that AHDD kit can replace HDD kit due to an increased stability for formulation, the better radiolabeling efficiency (78%) and the equivalent biodistribution pattern in mice.
ISSN
0969-8043 (Print)
Language
English
URI
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TJ0-4M0J4DP-3&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=3e41c04004cc24a1ba9bbd5044745eaf

http://hdl.handle.net/10371/26061
DOI
https://doi.org/10.1016/j.apradiso.2006.07.008
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College of Medicine/School of Medicine (의과대학/대학원)Nuclear Medicine (핵의학전공)Journal Papers (저널논문_핵의학전공)
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