Browse

Alpha-antitrypsin genotypes in Korean patients with chronic obstructive pulmonary disease

Cited 10 time in Web of Science Cited 8 time in Scopus
Authors
Kim, Cheol Hyeon; Yim, Jae-Joon; Yoo, Chul-Gyu; Lee, Choon-Taek; Kim, Young Whan; Han, Sung Koo; Shim, Young-Soo
Issue Date
2005-04-13
Publisher
Wiley-Blackwell
Citation
Respirology. 2005 Mar;10(2):223-8.
Keywords
AgedAged, 80 and overAllelesFemaleGene FrequencyGenotypeHumansKoreaMaleMiddle AgedPolymerase Chain Reaction*Polymorphism, GeneticPolymorphism, Restriction Fragment LengthPulmonary Disease, Chronic Obstructive/blood/*genetics/physiopathologyRespiratory Function Testsalpha 1-Antitrypsin/analysis/*genetics
Abstract
OBJECTIVE: Alpha1-antitrypsin (AAT) deficiency is a recognized susceptible factor for chronic obstructive pulmonary disease (COPD) in Western countries, but its importance in Korea is unclear. To date, no definitive case of alpha1-antitrypsin deficiency has been reported in Korea. This study aimed to clarify whether alpha1-antitrypsin deficiency exists and to determine the distribution of alpha1-antitrypsin alleles in the Korean population. METHODOLOGY: The serum concentrations of alpha1-antitrypsin were determined and polymorphisms of the alpha1-antitrypsin gene in 114 COPD patients and in 196 healthy controls were examined. Phenotyping by isoelectric focusing and the genotyping of alpha1-antitrypsin gene by polymerase chain reaction and restriction fragment length polymorphism were performed. RESULTS: No alpha1-antitrypsin level abnormality was found in the patients. M1(Val)/M1(Val) was found to be the most frequent genotype in both groups (69.2% and 66.8%, respectively), and M1(Val) the most frequent allele. The distributions of alpha1-antitrypsin alleles were similar in the patient and control groups, and no S or Z allele was found. CONCLUSION: Alpha1-antitrypsin deficiency is unlikely to be an important cause of chronic obstructive pulmonary disease in the Korean population.
ISSN
1323-7799 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15823189

http://hdl.handle.net/10371/26502
DOI
https://doi.org/10.1111/j.1440-1843.2005.00693.x
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse