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Genetic association study of adiponectin polymorphisms with risk of Type 2 diabetes mellitus in Korean population

Cited 55 time in Web of Science Cited 63 time in Scopus
Authors
Lee, Y Y; Lee, N S; Cho, Y M; Moon, M K; Jung, H S; Park, Y J; Park, H J; Youn, B S; Lee, H K; Park, K S; Shin, H D
Issue Date
2005-04-22
Publisher
Wiley-Blackwell
Citation
Diabet Med. 2005 May;22(5):569-75.
Keywords
AdiponectinAgedDiabetes Mellitus, Type 2/ethnology/*geneticsFemaleGenetic Predisposition to Disease/*geneticsHumansInsulin Resistance/ethnology/genetics*Intercellular Signaling Peptides and Proteins/geneticsKorea/ethnologyMaleMiddle AgedPolymorphism, Single Nucleotide/*genetics
Abstract
AIMS: To investigate any association between Type 2 diabetes mellitus and two single nucleotide polymorphisms (SNPs) in the adiponectin gene, T45G and G276T, in the Korean population. METHODS: We genotyped 427 non-diabetic controls and 493 Type 2 diabetic patients for SNPs T45G and G276T of adiponectin gene, measured plasma adiponectin concentrations, and examined clinical parameters in Koreans. RESULTS: There were no statistically significant differences in allele frequencies of SNPs 45 and 276 comparing control with Type 2 diabetic subjects (T frequency 68.3% vs. 71.6%, P=0.13 for SNP45, G frequency 72.2% vs. 68.9%, P=0.12 for SNP276). The genotype distributions of these SNPs had no association with the risk of Type 2 diabetes and metabolic parameters of insulin resistance. Plasma levels of adiponectin were not statistically different according to T45G and G276T either, in both control and Type 2 diabetic subjects. CONCLUSION: The T45G and G276T of the adiponectin gene may not be an important determinant of Type 2 diabetes or insulin resistance in Korean subjects.
ISSN
0742-3071 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15842511

http://hdl.handle.net/10371/26996
DOI
https://doi.org/10.1111/j.1464-5491.2005.01460.x
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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