S-Space College of Medicine/School of Medicine (의과대학/대학원) Internal Medicine (내과학전공) Journal Papers (저널논문_내과학전공)
Genetic association study of adiponectin polymorphisms with risk of Type 2 diabetes mellitus in Korean population
- Lee, Y Y; Lee, N S; Cho, Y M; Moon, M K; Jung, H S; Park, Y J; Park, H J; Youn, B S; Lee, H K; Park, K S; Shin, H D
- Issue Date
- Diabet Med. 2005 May;22(5):569-75.
- Adiponectin; Aged; Diabetes Mellitus, Type 2/ethnology/*genetics; Female; Genetic Predisposition to Disease/*genetics; Humans; Insulin Resistance/ethnology/genetics; *Intercellular Signaling Peptides and Proteins/genetics; Korea/ethnology; Male; Middle Aged; Polymorphism, Single Nucleotide/*genetics
- AIMS: To investigate any association between Type 2 diabetes mellitus and two single nucleotide polymorphisms (SNPs) in the adiponectin gene, T45G and G276T, in the Korean population. METHODS: We genotyped 427 non-diabetic controls and 493 Type 2 diabetic patients for SNPs T45G and G276T of adiponectin gene, measured plasma adiponectin concentrations, and examined clinical parameters in Koreans. RESULTS: There were no statistically significant differences in allele frequencies of SNPs 45 and 276 comparing control with Type 2 diabetic subjects (T frequency 68.3% vs. 71.6%, P=0.13 for SNP45, G frequency 72.2% vs. 68.9%, P=0.12 for SNP276). The genotype distributions of these SNPs had no association with the risk of Type 2 diabetes and metabolic parameters of insulin resistance. Plasma levels of adiponectin were not statistically different according to T45G and G276T either, in both control and Type 2 diabetic subjects. CONCLUSION: The T45G and G276T of the adiponectin gene may not be an important determinant of Type 2 diabetes or insulin resistance in Korean subjects.
- 0742-3071 (Print)
- Files in This Item: There are no files associated with this item.