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Genetic association study of adiponectin polymorphisms with risk of Type 2 diabetes mellitus in Korean population
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Y Y | - |
dc.contributor.author | Lee, N S | - |
dc.contributor.author | Cho, Y M | - |
dc.contributor.author | Moon, M K | - |
dc.contributor.author | Jung, H S | - |
dc.contributor.author | Park, Y J | - |
dc.contributor.author | Park, H J | - |
dc.contributor.author | Youn, B S | - |
dc.contributor.author | Lee, H K | - |
dc.contributor.author | Park, K S | - |
dc.contributor.author | Shin, H D | - |
dc.date.accessioned | 2010-01-06T08:14:34Z | - |
dc.date.available | 2010-01-06T08:14:34Z | - |
dc.date.issued | 2005-04-22 | - |
dc.identifier.citation | Diabet Med. 2005 May;22(5):569-75. | en |
dc.identifier.issn | 0742-3071 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15842511 | - |
dc.identifier.uri | https://hdl.handle.net/10371/26996 | - |
dc.description.abstract | AIMS: To investigate any association between Type 2 diabetes mellitus and two single nucleotide polymorphisms (SNPs) in the adiponectin gene, T45G and G276T, in the Korean population. METHODS: We genotyped 427 non-diabetic controls and 493 Type 2 diabetic patients for SNPs T45G and G276T of adiponectin gene, measured plasma adiponectin concentrations, and examined clinical parameters in Koreans. RESULTS: There were no statistically significant differences in allele frequencies of SNPs 45 and 276 comparing control with Type 2 diabetic subjects (T frequency 68.3% vs. 71.6%, P=0.13 for SNP45, G frequency 72.2% vs. 68.9%, P=0.12 for SNP276). The genotype distributions of these SNPs had no association with the risk of Type 2 diabetes and metabolic parameters of insulin resistance. Plasma levels of adiponectin were not statistically different according to T45G and G276T either, in both control and Type 2 diabetic subjects. CONCLUSION: The T45G and G276T of the adiponectin gene may not be an important determinant of Type 2 diabetes or insulin resistance in Korean subjects. | en |
dc.language.iso | en | - |
dc.publisher | Wiley-Blackwell | en |
dc.subject | Adiponectin | en |
dc.subject | Aged | en |
dc.subject | Diabetes Mellitus, Type 2/ethnology/*genetics | en |
dc.subject | Female | en |
dc.subject | Genetic Predisposition to Disease/*genetics | en |
dc.subject | Humans | en |
dc.subject | Insulin Resistance/ethnology/genetics | en |
dc.subject | Korea/ethnology | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Polymorphism, Single Nucleotide/*genetics | en |
dc.subject | Intercellular Signaling Peptides and Proteins/genetics | - |
dc.title | Genetic association study of adiponectin polymorphisms with risk of Type 2 diabetes mellitus in Korean population | en |
dc.type | Article | en |
dc.identifier.doi | 10.1111/j.1464-5491.2005.01460.x | - |
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