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Long-term survival of resectable subset after induction chemotherapy in patients with locally advanced head and neck cancer

Cited 6 time in Web of Science Cited 7 time in Scopus
Authors
Cho, Yo-Han; Lee, Se Hoon; Kim, Dong-Wan; Wu, Hong-Gyun; Hah, J. Hun; Rhee, Chae-Seo; Sung, Myung-Whun; Kim, Kwang Hyun; Heo, Dae Seog
Issue Date
2008-03
Publisher
Wiley-Blackwell
Citation
Head and Neck, Vol.30 No.3, pp.346-350
Keywords
neoadjuvant chemotherapylocally advanced head and neck cancerconcurrent chemoradiationsurvivalcurative surgery
Abstract
Background, Although meta-analysis showed that survival improved with concurrent chemoradiation in locally advanced head and neck cancer, neoadjuvant chemotherapy is still unique, because it renders curative surgery feasible for marginally resectable head and neck cancer patients. Methods. We reviewed patients with locally advanced head and neck cancer, who had been treated with neoadjuvant chemotherapy between June 1984 and February 2001 at the Seoul National University Hospital. Results. A total of 167 patients were included. After 2 to 3 chemotherapy cycles, either surgery (38 patients) or radiation (104 patients) was conducted. Those who received surgery exhibited better survival than those who received radiation [median survival: not reached vs 33.6 months (95% Cl: 22.6-44.7), p =.006]. The 5-year and 10-year survival rates of surgery group were 63.2% and 59.8%. Conclusion. The potential benefit of neoadjuvant chemotherapy with surgery in patients with locally advanced head and neck cancers merits further evaluation in future clinical trials. (c) 2007 Wiley Periodicals, Inc.
ISSN
1043-3074
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17972310

http://hdl.handle.net/10371/27042
DOI
https://doi.org/10.1002/hed.20713
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Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Cancer Research Institute (암연구소)Journal Papers (저널논문_암연구소)
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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