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Circulating beta amyloid protein is elevated in patients with acute ischemic stroke

Cited 44 time in Web of Science Cited 42 time in Scopus
Authors
Lee, P. H.; Bang, O. Y.; Hwang, E. M.; Lee, J. S.; Joo, U. S.; Mook-Jung, I.; Huh, K.
Issue Date
2005-02-01
Publisher
Springer Verlag
Citation
J Neural Transm. 2005 Oct;112(10):1371-9. Epub 2005 Jan 31.
Keywords
Acute DiseaseAgedAmyloid beta-Protein/*bloodBiological Markers/bloodBrain Ischemia/epidemiology/*metabolism/pathologyFemaleHumansMaleMiddle AgedP-Selectin/bloodPeptide Fragments/*bloodPlatelet ActivationProspective StudiesRisk FactorsSeverity of Illness IndexStroke/epidemiology/*metabolism/pathology
Abstract
Recent clinical and experimental studies suggest that ischemic strokes may play an important role in the pathogenesis of Alzheimer's disease (AD). Beta amyloid (Abeta), a major component of senile plaque in AD, is known to be derived from ischemic brain or activated platelets. We prospectively enrolled 62 patients with acute ischemic stroke and 27 age-matched controls. The serum Abeta and P-selectin levels were determined using the Sandwich-ELISA. We divided ischemic strokes into subgroups according to the clinical syndrome, pathogenesis, and infarct size, and compared the Abeta level between each subgroup. The Abeta1-40 level was markedly elevated in ischemic stroke patients, as compared to controls (140.2 +/- 54.0 vs 88.44 +/- 34.96 pg/ml, p<0.001). Cardioembolic and larger artery atherosclerotic infarcts had higher Abeta1-40 level than small vessel disease (p = 0.001). Both infarct size and the initial NIHSS score had significantly positive correlations with the serum level of Abeta1-40 (r = 0.539, p<0.001 and r = 0.425, p = 0.001, respectively). However, the P-selectin level was not significantly correlated with serum Abeta1-40. Our data suggest that elevated circulating Abeta1-40 in ischemic stroke patients may be derived from brain as a consequence of ischemic insults.
ISSN
0300-9564 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15682267

http://hdl.handle.net/10371/27194
DOI
https://doi.org/10.1007/s00702-004-0274-0
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Biochemistry & Molecular Biology (생화학교실)Journal Papers (저널논문_생화학교실)
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