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Circulating beta amyloid protein is elevated in patients with acute ischemic stroke
DC Field | Value | Language |
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dc.contributor.author | Lee, P. H. | - |
dc.contributor.author | Bang, O. Y. | - |
dc.contributor.author | Hwang, E. M. | - |
dc.contributor.author | Lee, J. S. | - |
dc.contributor.author | Joo, U. S. | - |
dc.contributor.author | Mook-Jung, I. | - |
dc.contributor.author | Huh, K. | - |
dc.date.accessioned | 2010-01-07 | - |
dc.date.available | 2010-01-07 | - |
dc.date.issued | 2005-02-01 | - |
dc.identifier.citation | J Neural Transm. 2005 Oct;112(10):1371-9. Epub 2005 Jan 31. | en |
dc.identifier.issn | 0300-9564 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15682267 | - |
dc.identifier.uri | https://hdl.handle.net/10371/27194 | - |
dc.description.abstract | Recent clinical and experimental studies suggest that ischemic strokes may play an important role in the pathogenesis of Alzheimer's disease (AD). Beta amyloid (Abeta), a major component of senile plaque in AD, is known to be derived from ischemic brain or activated platelets. We prospectively enrolled 62 patients with acute ischemic stroke and 27 age-matched controls. The serum Abeta and P-selectin levels were determined using the Sandwich-ELISA. We divided ischemic strokes into subgroups according to the clinical syndrome, pathogenesis, and infarct size, and compared the Abeta level between each subgroup. The Abeta1-40 level was markedly elevated in ischemic stroke patients, as compared to controls (140.2 +/- 54.0 vs 88.44 +/- 34.96 pg/ml, p<0.001). Cardioembolic and larger artery atherosclerotic infarcts had higher Abeta1-40 level than small vessel disease (p = 0.001). Both infarct size and the initial NIHSS score had significantly positive correlations with the serum level of Abeta1-40 (r = 0.539, p<0.001 and r = 0.425, p = 0.001, respectively). However, the P-selectin level was not significantly correlated with serum Abeta1-40. Our data suggest that elevated circulating Abeta1-40 in ischemic stroke patients may be derived from brain as a consequence of ischemic insults. | en |
dc.language.iso | en | en |
dc.publisher | Springer Verlag | en |
dc.subject | Acute Disease | en |
dc.subject | Aged | en |
dc.subject | Amyloid beta-Protein/*blood | en |
dc.subject | Biological Markers/blood | en |
dc.subject | Brain Ischemia/epidemiology/*metabolism/pathology | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | P-Selectin/blood | en |
dc.subject | Peptide Fragments/*blood | en |
dc.subject | Platelet Activation | en |
dc.subject | Prospective Studies | en |
dc.subject | Risk Factors | en |
dc.subject | Severity of Illness Index | en |
dc.subject | Stroke/epidemiology/*metabolism/pathology | en |
dc.title | Circulating beta amyloid protein is elevated in patients with acute ischemic stroke | en |
dc.type | Article | en |
dc.identifier.doi | 10.1007/s00702-004-0274-0 | - |
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