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Group I mGluR regulates the polarity of spike-timing dependent plasticity in substantia gelatinosa neurons

Cited 9 time in Web of Science Cited 11 time in Scopus
Authors
Jung, Sung Jun; Kim, Sang Jeong; Park, Yun Kyung; Oh, Seog Bae; Cho, Kwangwook; Kim, Jun
Issue Date
2006-07-14
Publisher
Elsevier
Citation
Biochem Biophys Res Commun. 2006 Aug 25;347(2):509-16. Epub 2006 Jun 30.
Keywords
2-Amino-5-phosphonovalerate/pharmacologyAnimalsBoron Compounds/pharmacologyCalcium/antagonists & inhibitors/metabolismCalcium ChannelsChelating Agents/pharmacologyEgtazic Acid/analogs & derivatives/pharmacologyEstrenes/pharmacologyExcitatory Amino Acid Antagonists/pharmacologyFemaleIndans/pharmacologyInositol 1,4,5-Trisphosphate ReceptorsLong-Term Potentiation/drug effects/physiologyLong-Term Synaptic Depression/drug effects/physiologyMaleNeuronal Plasticity/drug effects/*physiologyNeurons/drug effects/*physiologyPyrrolidinones/pharmacologyRatsRats, Sprague-DawleyReceptors, Cytoplasmic and Nuclear/antagonists & inhibitorsReceptors, Metabotropic Glutamate/antagonists & inhibitors/*physiologyStaurosporine/pharmacologySubstantia Gelatinosa/cytology/drug effects/*physiologySynaptic Transmission/drug effects/*physiologyTime FactorsType C Phospholipases/antagonists & inhibitors
Abstract
The spinal synaptic plasticity is associated with a central sensitization of nociceptive input, which accounts for the generation of hyperalgesia in chronic pain. However, how group I metabotropic glutamate receptors (mGluRs) may operate spinal plasticity remains essentially unexplored. Here, we have identified spike-timing dependent synaptic plasticity in substantia gelatinosa (SG) neurons, using perforated patch-clamp recordings of SG neuron in a spinal cord slice preparation. In the presence of bicuculline and strychnine, long-term potentiation (LTP) was blocked by AP-5 and Ca2+ chelator BAPTA-AM. The group I mGluR antagonist AIDA, PLC inhibitor U-73122, and IP3 receptor blocker 2-APB shifted LTP to long-term depression (LTD) without affecting acute synaptic transmission. These findings provide a link between postsynaptic group I mGluR/PLC/IP3-gated Ca2+ store regulating the polarity of synaptic plasticity and spinal central sensitization.
ISSN
0006-291X (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16836978

http://hdl.handle.net/10371/27289
DOI
https://doi.org/10.1016/j.bbrc.2006.06.134
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Physiology (생리학교실)Journal Papers (저널논문_생리학교실)
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