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Group I mGluR regulates the polarity of spike-timing dependent plasticity in substantia gelatinosa neurons
Cited 11 time in
Web of Science
Cited 13 time in Scopus
- Authors
- Issue Date
- 2006-07-14
- Publisher
- Elsevier
- Citation
- Biochem Biophys Res Commun. 2006 Aug 25;347(2):509-16. Epub 2006 Jun 30.
- Keywords
- 2-Amino-5-phosphonovalerate/pharmacology ; Animals ; Boron Compounds/pharmacology ; Calcium/antagonists & inhibitors/metabolism ; Calcium Channels ; Chelating Agents/pharmacology ; Egtazic Acid/analogs & derivatives/pharmacology ; Estrenes/pharmacology ; Excitatory Amino Acid Antagonists/pharmacology ; Female ; Indans/pharmacology ; Inositol 1,4,5-Trisphosphate Receptors ; Long-Term Potentiation/drug effects/physiology ; Long-Term Synaptic Depression/drug effects/physiology ; Male ; Neuronal Plasticity/drug effects/*physiology ; Neurons/drug effects/*physiology ; Pyrrolidinones/pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptors, Cytoplasmic and Nuclear/antagonists & inhibitors ; Receptors, Metabotropic Glutamate/antagonists & inhibitors/*physiology ; Staurosporine/pharmacology ; Substantia Gelatinosa/cytology/drug effects/*physiology ; Synaptic Transmission/drug effects/*physiology ; Time Factors ; Type C Phospholipases/antagonists & inhibitors
- Abstract
- The spinal synaptic plasticity is associated with a central sensitization of nociceptive input, which accounts for the generation of hyperalgesia in chronic pain. However, how group I metabotropic glutamate receptors (mGluRs) may operate spinal plasticity remains essentially unexplored. Here, we have identified spike-timing dependent synaptic plasticity in substantia gelatinosa (SG) neurons, using perforated patch-clamp recordings of SG neuron in a spinal cord slice preparation. In the presence of bicuculline and strychnine, long-term potentiation (LTP) was blocked by AP-5 and Ca2+ chelator BAPTA-AM. The group I mGluR antagonist AIDA, PLC inhibitor U-73122, and IP3 receptor blocker 2-APB shifted LTP to long-term depression (LTD) without affecting acute synaptic transmission. These findings provide a link between postsynaptic group I mGluR/PLC/IP3-gated Ca2+ store regulating the polarity of synaptic plasticity and spinal central sensitization.
- ISSN
- 0006-291X (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16836978
https://hdl.handle.net/10371/27289
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