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Transient activation of protein phosphatase 2A induced by electroconvulsive shock in the rat frontal cortex

Cited 11 time in Web of Science Cited 11 time in Scopus
Authors
Kang, Ung Gu; Jeon, Won Je; Kim, Yeni; Chung, Chun Kee; Park, Joo Bae; Juhnn, Yong Sung; Kim, Yong Sik
Issue Date
2005-09-07
Publisher
Elsevier
Citation
Neurosci Lett. 2005 Dec 30;390(3):171-5. Epub 2005 Sep 6.
Keywords
Analysis of VarianceAnimalsBlotting, Western/methodsDose-Response Relationship, RadiationElectroshock/*methodsEnzyme Activation/radiation effectsFrontal Lobe/metabolism/*radiation effectsGene Expression Regulation/*radiation effectsMalePhosphoprotein Phosphatases/*metabolismPhosphorylation/radiation effectsProtein Kinases/metabolismProtein Phosphatase 2RatsRats, Sprague-DawleySerine/metabolismThreonine/metabolismTime Factors
Abstract
We have attempted to determine the effects of electroconvulsive shock (ECS) on protein phosphatase 2A (PP2A) in the frontal cortices of rats. PP2A exhibited a 30% increase in activity immediately after ECS treatment. Immunoblot analysis revealed that phosphorylation signals, including protein kinase B (Akt/PKB), glycogen synthase kinase-3beta (GSK-3beta), and cyclic adenosine monophosphate response element binding protein (CREB) were reduced immediately after ECS treatment. When an additional ECS was administered after the activation of these kinases, the immediate reactivation of PP2A overrode the kinase activity. ECS induces transient PP2A activation prior to kinase activation, and this pattern of activity may induce the biphasic phosphorylation of substrate proteins.
ISSN
0304-3940 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16143450

http://hdl.handle.net/10371/27441
DOI
https://doi.org/10.1016/j.neulet.2005.08.020
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Biochemistry & Molecular Biology (생화학교실)Journal Papers (저널논문_생화학교실)
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