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IGF2 polymorphisms are associated with hepatitis B virus clearance and hepatocellular carcinoma

Cited 21 time in Web of Science Cited 20 time in Scopus
Authors
Kim, Yoon Jun; Yoon, Jung-Hwan; Kim, Chung Yong; Kim, Lyoung Hyo; Park, Byung Lae; Shin, Hyoung Doo; Lee, Hyo-Suk
Issue Date
2006-06-06
Publisher
Elsevier
Citation
Biochem Biophys Res Commun. 2006 Jul 21;346(1):38-44. Epub 2006 May 24.
Keywords
AdultAge FactorsAgedAsian Continental Ancestry Group/geneticsCarcinoma, Hepatocellular/etiology/*geneticsFemaleHaplotypesHepatitis B virus/immunologyHepatitis B, Chronic/genetics/*virologyHumansInsulin-Like Growth Factor IIKoreaMaleMiddle AgedPolymorphism, Genetic/*geneticsPolymorphism, Single NucleotideProspective StudiesProteins/*genetics
Abstract
The aim of this study was to determine whether IGF2 polymorphisms are associated with the clearance of hepatitis B virus (HBV) infection and the risk of hepatocellular carcinoma (HCC). A total of 1095 Korean subjects were prospectively enrolled in this case-control study. The rates of IGF2 polymorphisms were determined in each group. The IGF2+820G allele (IGF2+820G/G) and the IGF2+6815A/A genotype were strongly associated with the resolution of HBV infection (OR=0.62-0.73; P=0.001-0.03 and OR=0.71; P=0.03, respectively). Haplotype analysis showed that IGF2-haplotype5 (A-C-C-T-A-T-G) and IGF2-haplotype1 (T-C-T-T-A-C-A) were significantly associated with the clearance and persistence of HBV infection (OR=0.55-0.58, P=0.009-0.01 and OR=1.31-1.65, P=0.001-0.007, respectively). On the other hand, the IGF2+2482C/C or +820G/G genotypes were significantly associated with a higher risk of HCC (OR=1.88, 1.68; P=0.04). IGF2 polymorphisms were found to be strongly associated with the clearance of HBV or the occurrence of HCC in patients with chronic HBV infection.
ISSN
0006-291X (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16750516

http://hdl.handle.net/10371/27451
DOI
https://doi.org/10.1016/j.bbrc.2006.05.080
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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