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Genetic polymorphisms in peroxisome proliferator-activated receptor gamma are associated with Type 2 diabetes mellitus and obesity in the Korean population
DC Field | Value | Language |
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dc.contributor.author | Moon, M K | - |
dc.contributor.author | Cho, Y M | - |
dc.contributor.author | Jung, H S | - |
dc.contributor.author | Park, Y J | - |
dc.contributor.author | Yoon, K H | - |
dc.contributor.author | Sung, Y A | - |
dc.contributor.author | Park, B L | - |
dc.contributor.author | Lee, H K | - |
dc.contributor.author | Park, K S | - |
dc.contributor.author | Shin, H D | - |
dc.date.accessioned | 2010-01-07T01:12:26Z | - |
dc.date.available | 2010-01-07T01:12:26Z | - |
dc.date.issued | 2005-08-20 | - |
dc.identifier.citation | Diabet Med. 2005 Sep;22(9):1161-6. | en |
dc.identifier.issn | 0742-3071 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16108843 | - |
dc.identifier.uri | https://hdl.handle.net/10371/27578 | - |
dc.description.abstract | AIMS: We examined whether the common polymorphisms of the peroxisome proliferator-activated receptor-gamma (PPARgamma) gene are associated with Type 2 diabetes or obesity in the Korean population. METHODS: We genotyped two common PPARgamma polymorphisms (Pro12Ala and 161C > T) and examined their association with the clinical phenotypes found in 684 patients with Type 2 diabetes mellitus and 291 non-diabetic control subjects. RESULTS: The 12Ala allele was less frequent in the Type 2 diabetic patients than in the non-diabetic control subjects (0.036 vs. 0.053, P = 0.024). The allele frequencies of the 161C > T polymorphism did not differ between the control and Type 2 diabetic group (0.158 vs. 0.173). In the non-diabetic controls, those with the T allele had lower BMI and fasting serum triglyceride (TG) concentrations than those with the C/C homozygote (22.7 +/- 2.9 vs. 23.8 +/- 3.2 kg/m2, P = 0.002; 1.45 +/- 0.81 vs. 1.65 +/- 0.83 mmol/l, P = 0.03, respectively). The 12Ala-161T haplotype was associated with a decreased risk for Type 2 diabetes (OR = 0.47, P = 0.009), whereas the 12Pro-161T haplotype was associated with lower BMI and lower fasting serum TG (22.5 +/- 2.8 vs. 23.7 +/- 3.2 kg/m2, P = 0.004; 1.41 +/- 0.87 vs. 1.64 +/- 0.79 mmol/l, P = 0.02, respectively). CONCLUSIONS: The PPARgamma 12Ala allele was associated with a reduced risk of Type 2 diabetes, whereas the PPARgamma 161T allele was associated with lower BMI and fasting serum TG concentrations in the Korean subjects. The subjects with 12Ala-161T haplotypes had a reduced risk of Type 2 diabetes. | en |
dc.language.iso | en | - |
dc.publisher | Wiley-Blackwell | en |
dc.subject | Alleles | en |
dc.subject | Body Mass Index | en |
dc.subject | Diabetes Mellitus, Type 2/epidemiology/*genetics | en |
dc.subject | Female | en |
dc.subject | Gene Frequency | en |
dc.subject | Genotype | en |
dc.subject | Haplotypes | en |
dc.subject | Humans | en |
dc.subject | Korea/epidemiology | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Obesity/epidemiology/*genetics | en |
dc.subject | PPAR gamma/*genetics | en |
dc.subject | Polymorphism, Genetic/*genetics | en |
dc.subject | Population Surveillance/methods | en |
dc.subject | Triglycerides/blood | en |
dc.title | Genetic polymorphisms in peroxisome proliferator-activated receptor gamma are associated with Type 2 diabetes mellitus and obesity in the Korean population | en |
dc.type | Article | en |
dc.identifier.doi | 10.1111/j.1464-5491.2005.01599.x | - |
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