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Prognostic significance of loss of c-fos protein in gastric carcinoma

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Authors
Jin, Seon Pil; Kim, Ji Hun; Kim, Min A; Yang, Han-Kwang; Lee, Hee Eun; Lee, Hye Seung; Kim, Woo Ho
Issue Date
2007-12-26
Publisher
Elsevier
Citation
Pathol Oncol Res. 2007;13(4):284-9. Epub 2007 Dec 25.
Keywords
Carcinoma/metabolism/mortality/*pathologyDisease ProgressionFemaleHumansMalePrognosisProto-Oncogene Proteins c-fos/*metabolismStomach Neoplasms/metabolism/mortality/*pathologySurvival Rate
Abstract
c-fos was first identified as a viral oncoprotein, and has been studied in terms of its oncogenic function in tumorigenesis. Many experimental and clinical data indicated that c-fos expression plays a role in the progression of several types of carcinomas. However, some recent studies challenge this view as they indicate that c-fos has tumor suppressor activity. In the present study, we assessed c-fos protein expression in 625 consecutive gastric cancers immunohistochemically, and analyzed its relationship with clinicopathologic factors and survival. We found that a loss of c-fos expression is correlated with a more advanced stage, lymph node metastasis, lymphatic invasion and shorter survival, indicating that c-fos expression in gastric cancer cells is lost during progression and that this loss is associated with a poor prognosis. The above findings suggest that loss of c-fos expression has tumor suppressor activity in gastric cancer and we suspect that this suppressor activity might be related to the pro-apoptotic function of c-fos.
ISSN
1219-4956 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18158562

http://hdl.handle.net/10371/27679
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College of Medicine/School of Medicine (의과대학/대학원)Program in Cancer Biology (협동과정-종양생물학전공)Journal Papers (저널논문_협동과정-종양생물학전공)
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