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Assessment of regional GABA(A) receptor binding using 18F-fluoroflumazenil positron emission tomography in spastic type cerebral palsy

Cited 16 time in Web of Science Cited 17 time in Scopus
Authors
Lee, Jong Doo; Park, Hae-Jeong; Park, Eun Sook; Kim, Dong Goo; Rha, Dong-Wook; Kim, Eung Yeop; Kim, Dong Ik; Kim, Jae-Jin; Yun, Mijin; Ryu, Young Hoon; Lee, Jinu; Jeong, Jae Min; Lee, Dong Soo; Lee, Myung Chul; Park, Chang Il
Issue Date
2006-10-20
Publisher
Elsevier
Citation
Neuroimage. 2007 Jan 1;34(1):19-25. Epub 2006 Oct 13.
Keywords
AdolescentAdultBinding SitesBrain Stem/physiopathology/radionuclide imagingCerebral Palsy/*physiopathology/*radionuclide imagingChildFemaleFlumazenil/*analogs & derivatives/diagnostic useFluorine Radioisotopes/*diagnostic useHumansMaleMotor Cortex/physiopathology/radionuclide imaging*Positron-Emission TomographyReceptors, GABA-A/*physiology
Abstract
Periventricular leukomalacia (PVL) due to hypoxic-ischemic insult to the immature brain, chorioamnionitis and maternal infection are the major etiological factors of spastic type cerebral palsy (CP). Despite advances in preventing and treating certain causes of CP, the number of patients has remained essentially unchanged and the pathophysiological mechanisms related to motor dysfunction remain poorly understood. In this study, statistical parametric mapping (SPM) analysis of cerebral gamma-aminobutyric acid (GABA) receptor PET imaging using [18F]-fluoroflumazenil showed increased GABA(A) receptor binding in the bilateral motor and visual cortices in spastic diplegia (SD) type CP patients (n = 20) compared with normal controls (n = 10). As GABA(A) receptor signaling modulates biological perception and production of movement, complex motor skills and use-dependent plasticity in the motor cortex, increased GABA(A) receptor binding in the motor cortex might play a important role in poor motor control. Decreased GABA(A) receptor binding was seen in the brain stem in SD CP patients, which appears to be related to spastic symptom.
ISSN
1053-8119 (Print)
Language
English
URI
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WNP-4M3RP4W-2&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=988e7a3799a4957501a92c670fb95ead

http://hdl.handle.net/10371/27723
DOI
https://doi.org/10.1016/j.neuroimage.2006.09.004
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College of Medicine/School of Medicine (의과대학/대학원)Nuclear Medicine (핵의학전공)Journal Papers (저널논문_핵의학전공)
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