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Fulminant type 1 diabetes in Korea: high prevalence among patients with adult-onset type 1 diabetes
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, Y M | - |
dc.contributor.author | Kim, J T | - |
dc.contributor.author | Ko, K S | - |
dc.contributor.author | Koo, B K | - |
dc.contributor.author | Yang, S W | - |
dc.contributor.author | Park, M H | - |
dc.contributor.author | Lee, H K | - |
dc.contributor.author | Park, K S | - |
dc.date.accessioned | 2010-01-07T02:24:29Z | - |
dc.date.available | 2010-01-07T02:24:29Z | - |
dc.date.issued | 2007-08-29 | - |
dc.identifier.citation | Diabetologia. 2007 Nov;50(11):2276-9. Epub 2007 Aug 28. | en |
dc.identifier.issn | 0012-186X (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17724575 | - |
dc.identifier.uri | https://hdl.handle.net/10371/27866 | - |
dc.description.abstract | AIMS/HYPOTHESIS: The aim of this study was to investigate the prevalence of fulminant type 1 diabetes and the clinical characteristics of the disease among newly diagnosed Korean patients. METHODS: Using data retrieved from the Seoul National University Hospital database, we identified all patients newly diagnosed with type 1 diabetes from 1 January 1999 to 31 July 2006. Information on clinical manifestations and laboratory data, including the presence of islet autoantibodies detected at diagnosis, were obtained by reviewing medical records. RESULTS: We identified 99 patients newly diagnosed with type 1 diabetes. Seven patients (7.1%) fulfilled the criteria for fulminant type 1 diabetes. Among the patients aged > or =18 years at onset, 30.4% had fulminant type 1 diabetes. Patients with this diabetes subtype tested negative for islet autoantibodies, had a higher age of onset (median 28 vs 10 years, p < 0.001) and a markedly shorter duration from onset of hyperglycaemic symptoms to first hospital visit (median 3 vs 30 days, p < 0.001) than patients with non-fulminant type 1 diabetes, and showed trends of increased serum aspartate aminotransferase and amylase levels and a decreased glucagon-stimulated serum C-peptide response. CONCLUSIONS/INTERPRETATION: In Korea, the prevalence of fulminant type 1 diabetes was 7.1% among all patients newly diagnosed with type 1 diabetes and 30.4% among patients with adult-onset diabetes. The clinical and metabolic characteristics of the patients with fulminant type 1 diabetes were similar to those reported in Japanese studies. | en |
dc.language.iso | en | en |
dc.publisher | Springer Verlag | en |
dc.subject | Adult | en |
dc.subject | Age Distribution | en |
dc.subject | Age of Onset | en |
dc.subject | Autoantibodies/blood | en |
dc.subject | Diabetes Mellitus, Type 1/*epidemiology/genetics | en |
dc.subject | Female | en |
dc.subject | Genotype | en |
dc.subject | HLA Antigens | en |
dc.subject | Humans | en |
dc.subject | Korea/epidemiology | en |
dc.subject | Male | en |
dc.subject | Prevalence | en |
dc.title | Fulminant type 1 diabetes in Korea: high prevalence among patients with adult-onset type 1 diabetes | en |
dc.type | Article | en |
dc.identifier.doi | 10.1007/s00125-007-0812-z | - |
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