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Fulminant type 1 diabetes in Korea: high prevalence among patients with adult-onset type 1 diabetes

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dc.contributor.authorCho, Y M-
dc.contributor.authorKim, J T-
dc.contributor.authorKo, K S-
dc.contributor.authorKoo, B K-
dc.contributor.authorYang, S W-
dc.contributor.authorPark, M H-
dc.contributor.authorLee, H K-
dc.contributor.authorPark, K S-
dc.date.accessioned2010-01-07T02:24:29Z-
dc.date.available2010-01-07T02:24:29Z-
dc.date.issued2007-08-29-
dc.identifier.citationDiabetologia. 2007 Nov;50(11):2276-9. Epub 2007 Aug 28.en
dc.identifier.issn0012-186X (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17724575-
dc.identifier.urihttps://hdl.handle.net/10371/27866-
dc.description.abstractAIMS/HYPOTHESIS: The aim of this study was to investigate the prevalence of fulminant type 1 diabetes and the clinical characteristics of the disease among newly diagnosed Korean patients. METHODS: Using data retrieved from the Seoul National University Hospital database, we identified all patients newly diagnosed with type 1 diabetes from 1 January 1999 to 31 July 2006. Information on clinical manifestations and laboratory data, including the presence of islet autoantibodies detected at diagnosis, were obtained by reviewing medical records. RESULTS: We identified 99 patients newly diagnosed with type 1 diabetes. Seven patients (7.1%) fulfilled the criteria for fulminant type 1 diabetes. Among the patients aged > or =18 years at onset, 30.4% had fulminant type 1 diabetes. Patients with this diabetes subtype tested negative for islet autoantibodies, had a higher age of onset (median 28 vs 10 years, p < 0.001) and a markedly shorter duration from onset of hyperglycaemic symptoms to first hospital visit (median 3 vs 30 days, p < 0.001) than patients with non-fulminant type 1 diabetes, and showed trends of increased serum aspartate aminotransferase and amylase levels and a decreased glucagon-stimulated serum C-peptide response. CONCLUSIONS/INTERPRETATION: In Korea, the prevalence of fulminant type 1 diabetes was 7.1% among all patients newly diagnosed with type 1 diabetes and 30.4% among patients with adult-onset diabetes. The clinical and metabolic characteristics of the patients with fulminant type 1 diabetes were similar to those reported in Japanese studies.en
dc.language.isoenen
dc.publisherSpringer Verlagen
dc.subjectAdulten
dc.subjectAge Distributionen
dc.subjectAge of Onseten
dc.subjectAutoantibodies/blooden
dc.subjectDiabetes Mellitus, Type 1/*epidemiology/geneticsen
dc.subjectFemaleen
dc.subjectGenotypeen
dc.subjectHLA Antigensen
dc.subjectHumansen
dc.subjectKorea/epidemiologyen
dc.subjectMaleen
dc.subjectPrevalenceen
dc.titleFulminant type 1 diabetes in Korea: high prevalence among patients with adult-onset type 1 diabetesen
dc.typeArticleen
dc.identifier.doi10.1007/s00125-007-0812-z-
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