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Intracellular domains of amyloid precursor-like protein 2 interact with CP2 transcription factor in the nucleus and induce glycogen synthase kinase-3beta expression
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Xu, Y. | - |
dc.contributor.author | Kim, H. S. | - |
dc.contributor.author | Joo, Y. | - |
dc.contributor.author | Choi, Y. | - |
dc.contributor.author | Chang, K. A. | - |
dc.contributor.author | Park, C. H. | - |
dc.contributor.author | Shin, K. Y. | - |
dc.contributor.author | Kim, S. | - |
dc.contributor.author | Cheon, Y. H. | - |
dc.contributor.author | Baik, T. K. | - |
dc.contributor.author | Kim, J. H. | - |
dc.contributor.author | Suh, Y. H. | - |
dc.date.accessioned | 2010-01-07T04:57:44Z | - |
dc.date.available | 2010-01-07T04:57:44Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Cell Death and Differentiation 2007; 14: 79-91 | en |
dc.identifier.issn | 1350-9047 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16645641 | - |
dc.identifier.uri | https://hdl.handle.net/10371/28184 | - |
dc.description.abstract | Amyloid precursor protein (APP) is a member of a gene family that includes two APP-like proteins, APLP1 and 2. Recently, it has been reported that APLP1 and 2 undergo presenilin-dependent gamma-secretase cleavage, as does APP, resulting in the release of an approximately 6 kDa intracellular C-terminal domain (ICD), which can translocate into the nucleus. In this study, we demonstrate that the APLP2-ICDs interact with CP2/LSF/LBP1 (CP2) transcription factor in the nucleus and induce the expression of glycogen synthase kinase 3beta (GSK-3beta), which has broad-ranged substrates such as tau- and beta-catenin. The significance of this finding is substantiated by the in vivo evidence of the increase in the immunoreactivities for the nuclear C-terminal fragments of APLP2, and for GSK-3beta in the AD patients' brain. Taken together, these results suggest that APLP2-ICDs contribute to the AD pathogenesis, by inducing GSK-3beta expression through the interaction with CP2 transcription factor in the nucleus. | en |
dc.language.iso | en | en |
dc.publisher | Nature Publishing Group | en |
dc.subject | Active Transport, Cell Nucleus | en |
dc.subject | Alzheimer Disease/*metabolism/pathology | en |
dc.subject | Amyloid beta-Protein Precursor/analysis/chemistry/genetics/*metabolism | en |
dc.subject | Animals | en |
dc.subject | Brain/*metabolism | en |
dc.subject | Brain Chemistry | en |
dc.subject | Cell Line | en |
dc.subject | Cell Nucleus/*metabolism | en |
dc.subject | DNA-Binding Proteins/*metabolism | en |
dc.subject | Fluorescence Resonance Energy Transfer | en |
dc.subject | Glycogen Synthase Kinase 3/analysis/*metabolism | en |
dc.subject | Green Fluorescent Proteins/genetics | en |
dc.subject | Humans | en |
dc.subject | Immunohistochemistry | en |
dc.subject | Matched-Pair Analysis | en |
dc.subject | Mice | en |
dc.subject | Nerve Tissue Proteins/analysis/genetics/metabolism | en |
dc.subject | Neurons/metabolism | en |
dc.subject | Nuclear Proteins/genetics/metabolism | en |
dc.subject | PC12 Cells | en |
dc.subject | Phosphorylation | en |
dc.subject | Point Mutation | en |
dc.subject | Protein Structure, Tertiary | en |
dc.subject | Rats | en |
dc.subject | Transcription Factors/*metabolism | en |
dc.subject | Transfection | en |
dc.subject | Up-Regulation | en |
dc.subject | tau Proteins/metabolism | en |
dc.title | Intracellular domains of amyloid precursor-like protein 2 interact with CP2 transcription factor in the nucleus and induce glycogen synthase kinase-3beta expression | en |
dc.type | Article | en |
dc.identifier.doi | 10.1038/sj.cdd.4401928 | - |
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