Publications
Detailed Information
A common coding variant in CASP8 is associated with breast cancer risk
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cox, Angela | - |
dc.contributor.author | Dunning, Alison M | - |
dc.contributor.author | Garcia-Closas, Montserrat | - |
dc.contributor.author | Balasubramanian, Sabapathy | - |
dc.contributor.author | Reed, Malcolm W R | - |
dc.contributor.author | Pooley, Karen A | - |
dc.contributor.author | Scollen, Serena | - |
dc.contributor.author | Baynes, Caroline | - |
dc.contributor.author | Ponder, Bruce A J | - |
dc.contributor.author | Chanock, Stephen | - |
dc.contributor.author | Lissowska, Jolanta | - |
dc.contributor.author | Brinton, Louise | - |
dc.contributor.author | Peplonska, Beata | - |
dc.contributor.author | Southey, Melissa C | - |
dc.contributor.author | Hopper, John L | - |
dc.contributor.author | McCredie, Margaret R E | - |
dc.contributor.author | Giles, Graham G | - |
dc.contributor.author | Fletcher, Olivia | - |
dc.contributor.author | Johnson, Nichola | - |
dc.contributor.author | dos Santos Silva, Isabel | - |
dc.contributor.author | Gibson, Lorna | - |
dc.contributor.author | Bojesen, Stig E | - |
dc.contributor.author | Nordestgaard, Borge G | - |
dc.contributor.author | Axelsson, Christen K | - |
dc.contributor.author | Torres, Diana | - |
dc.contributor.author | Hamann, Ute | - |
dc.contributor.author | Justenhoven, Christina | - |
dc.contributor.author | Brauch, Hiltrud | - |
dc.contributor.author | Chang-Claude, Jenny | - |
dc.contributor.author | Kropp, Silke | - |
dc.contributor.author | Risch, Angela | - |
dc.contributor.author | Wang-Gohrke, Shan | - |
dc.contributor.author | Schurmann, Peter | - |
dc.contributor.author | Bogdanova, Natalia | - |
dc.contributor.author | Dork, Thilo | - |
dc.contributor.author | Fagerholm, Rainer | - |
dc.contributor.author | Aaltonen, Kirsimari | - |
dc.contributor.author | Blomqvist, Carl | - |
dc.contributor.author | Nevanlinna, Heli | - |
dc.contributor.author | Seal, Sheila | - |
dc.contributor.author | Renwick, Anthony | - |
dc.contributor.author | Stratton, Michael R | - |
dc.contributor.author | Rahman, Nazneen | - |
dc.contributor.author | Sangrajrang, Suleeporn | - |
dc.contributor.author | Hughes, David | - |
dc.contributor.author | Odefrey, Fabrice | - |
dc.contributor.author | Brennan, Paul | - |
dc.contributor.author | Spurdle, Amanda B | - |
dc.contributor.author | Chenevix-Trench, Georgia | - |
dc.contributor.author | Beesley, Jonathan | - |
dc.contributor.author | Mannermaa, Arto | - |
dc.contributor.author | Hartikainen, Jaana | - |
dc.contributor.author | Kataja, Vesa | - |
dc.contributor.author | Kosma, Veli-Matti | - |
dc.contributor.author | Couch, Fergus J | - |
dc.contributor.author | Olson, Janet E | - |
dc.contributor.author | Goode, Ellen L | - |
dc.contributor.author | Broeks, Annegien | - |
dc.contributor.author | Schmidt, Marjanka K | - |
dc.contributor.author | Hogervorst, Frans B L | - |
dc.contributor.author | Van't Veer, Laura J | - |
dc.contributor.author | Kang, Daehee | - |
dc.contributor.author | Yoo, Keun-Young | - |
dc.contributor.author | Noh, Dong-Young | - |
dc.contributor.author | Ahn, Sei-Hyun | - |
dc.contributor.author | Wedren, Sara | - |
dc.contributor.author | Hall, Per | - |
dc.contributor.author | Low, Yen-Ling | - |
dc.contributor.author | Liu, Jianjun | - |
dc.contributor.author | Milne, Roger L | - |
dc.contributor.author | Ribas, Gloria | - |
dc.contributor.author | Gonzalez-Neira, Anna | - |
dc.contributor.author | Benitez, Javier | - |
dc.contributor.author | Sigurdson, Alice J | - |
dc.contributor.author | Stredrick, Denise L | - |
dc.contributor.author | Alexander, Bruce H | - |
dc.contributor.author | Struewing, Jeffery P | - |
dc.contributor.author | Pharoah, Paul D P | - |
dc.contributor.author | Easton, Douglas F | - |
dc.date.accessioned | 2010-01-07T05:03:03Z | - |
dc.date.available | 2010-01-07T05:03:03Z | - |
dc.date.issued | 2007-02-13 | - |
dc.identifier.citation | Nat Genet. 2007 Mar;39(3):352-8. Epub 2007 Feb 11. | en |
dc.identifier.issn | 1061-4036 (Print) | - |
dc.identifier.uri | http://www.nature.com/ng/journal/v39/n3/abs/ng1981.html | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17293864 | - |
dc.identifier.uri | https://hdl.handle.net/10371/28201 | - |
dc.description.abstract | The Breast Cancer Association Consortium (BCAC) has been established to conduct combined case-control analyses with augmented statistical power to try to confirm putative genetic associations with breast cancer. We genotyped nine SNPs for which there was some prior evidence of an association with breast cancer: CASP8 D302H (rs1045485), IGFBP3 -202 C --> A (rs2854744), SOD2 V16A (rs1799725), TGFB1 L10P (rs1982073), ATM S49C (rs1800054), ADH1B 3' UTR A --> G (rs1042026), CDKN1A S31R (rs1801270), ICAM5 V301I (rs1056538) and NUMA1 A794G (rs3750913). We included data from 9-15 studies, comprising 11,391-18,290 cases and 14,753-22,670 controls. We found evidence of an association with breast cancer for CASP8 D302H (with odds ratios (OR) of 0.89 (95% confidence interval (c.i.): 0.85-0.94) and 0.74 (95% c.i.: 0.62-0.87) for heterozygotes and rare homozygotes, respectively, compared with common homozygotes; P(trend) = 1.1 x 10(-7)) and weaker evidence for TGFB1 L10P (OR = 1.07 (95% c.i.: 1.02-1.13) and 1.16 (95% c.i.: 1.08-1.25), respectively; P(trend) = 2.8 x 10(-5)). These results demonstrate that common breast cancer susceptibility alleles with small effects on risk can be identified, given sufficiently powerful studies. | en |
dc.language.iso | en | - |
dc.publisher | Nature Publishing Group | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Breast Neoplasms/*genetics | en |
dc.subject | Case-Control Studies | en |
dc.subject | Caspase 8/*genetics | en |
dc.subject | Cohort Studies | en |
dc.subject | Female | en |
dc.subject | Genetic Variation | en |
dc.subject | Genotype | en |
dc.subject | Humans | en |
dc.subject | Middle Aged | en |
dc.subject | Polymorphism, Single Nucleotide | en |
dc.subject | Risk Factors | en |
dc.subject | Genetic Predisposition to Disease | - |
dc.title | A common coding variant in CASP8 is associated with breast cancer risk | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 강대희 | - |
dc.contributor.AlternativeAuthor | 유건영 | - |
dc.contributor.AlternativeAuthor | 노동영 | - |
dc.contributor.AlternativeAuthor | 안세현 | - |
dc.identifier.doi | 10.1038/ng1981 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.