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Regional cerebral perfusion abnormalities in developmental language disorder. Statistical parametric mapping analysis

Cited 6 time in Web of Science Cited 8 time in Scopus
Authors
Hwang, Jun Won; Lee, Jeong-Bum; Kim, Boong-Nyun; Lee, Ho-Young; Lee, Dong-Soo; Shin, Min-Sup; Cho, Soo-Churl
Issue Date
2006-04-19
Publisher
Springer Verlag
Citation
Eur Arch Psychiatry Clin Neurosci. 2006 Apr;256(3):131-7. Epub 2006 Apr 20.
Keywords
Age FactorsBrain/blood supplyBrain Mapping/*methodsCerebrovascular Disorders/*radionuclide imagingChild, PreschoolFemaleHumansLanguage Development Disorders/*radionuclide imagingMaleRegional Blood FlowTechnetium Tc 99m Exametazime/diagnostic useTomography, Emission-Computed, Single-Photon/statistics & numerical data
Abstract
OBJECTIVE: A voxel based investigation of cerebral blood flow was conducted to identify brain functional differences during resting state between children with developmental language disorder (DLD) and normal controls. METHOD: Using DSM-IV criteria, we selected 21 children with DLD.All children were examined by technetium-99m-HMPAO Brain SPECT. Using SPM analyses, we compared the SPECT images of children with DLD and those of 17 control subjects on a voxel by voxel basis using ANCOVA covarying for age. RESULTS: Reduced cerebral blood flow in the right putamen,the right inferior parietal cortex, and the left globus pallidus were found in children with DLD versus the controls. However, no area of increased cerebral blood flow was observed in children with DLD compared to the controls. CONCLUSION: Though results should be interpreted cautiously, this study confirms the presence of functional defects in the basal ganglia and the inferior parietal lobe during the resting state of the brains of children with DLD. It also gives further evidence for functional deficits in basal ganglia as an important factor in the etiology of DLD.
ISSN
0940-1334 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16619116

http://hdl.handle.net/10371/28462
DOI
https://doi.org/10.1007/s00406-006-0613-2
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College of Medicine/School of Medicine (의과대학/대학원)Nuclear Medicine (핵의학전공)Journal Papers (저널논문_핵의학전공)
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