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Molecular epidemiology of hepatitis B virus (HBV) genotypes and serotypes in patients with chronic HBV infection in Korea

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dc.contributor.authorKim, Hong-
dc.contributor.authorJee, Young Mee-
dc.contributor.authorSong, Byung-Cheol-
dc.contributor.authorShin, Jung Woo-
dc.contributor.authorYang, Soo Hyun-
dc.contributor.authorMun, Ho-Suk-
dc.contributor.authorKim, Hyun-Ju-
dc.contributor.authorOh, Eun-Ju-
dc.contributor.authorYoon, Jung-Hwan-
dc.contributor.authorKim, Yoon-Jun-
dc.contributor.authorLee, Hyo-Suk-
dc.contributor.authorHwang, Eung-Soo-
dc.contributor.authorCha, Chang-Yong-
dc.contributor.authorKook, Yoon-Hoh-
dc.contributor.authorKim, Bum-Jun-
dc.date.accessioned2010-01-07T06:45:06Z-
dc.date.available2010-01-07T06:45:06Z-
dc.date.issued2006-12-14-
dc.identifier.citationIntervirology. 2007;50(1):52-7. Epub 2006 Nov 24.en
dc.identifier.issn0300-5526 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17164558-
dc.identifier.urihttp://hdl.handle.net/10371/28480-
dc.description.abstractOBJECTIVES: Although hepatitis B virus (HBV) is endemic to Korea, no large-scale survey of HBV genotypes and serotypes based on sequence analysis has been performed. METHODS: In the present study, we genotyped and serotyped HBV strains from 209 patients in two Korean regions, Seoul (107 patients) and Jeju (102 patients), an island off the southeastern Korean coast. Analyses were conducted using the direct sequencing method targeting the partial surface (S) gene (541 bp). RESULTS: Phylogenetic analysis showed that all HBV strains from the 209 patients belonged to genotype C2 (100%). Of the 209 patients, 193 (92.3%), 12 (5.7%) and 1 (0.5%) were found to have the adr, adw and ayr serotypes, respectively. The other three strains (1.5%) showed unique serotype and were not typeable by sequence analysis. No HBV strains characteristic of Jeju island were observed. CONCLUSIONS: The extraordinary predominance of genotype C2 in chronic Korean patients, which is known to be associated with more severe liver disease than genotype B, suggests that the clinical manifestations of Korean HBV chronic patients are likely to differ from those found in other Asian countries, especially in Japan and Taiwan, where genotypes B and C coexist.en
dc.language.isoen-
dc.publisherS. Karger AGen
dc.subjectAdulten
dc.subjectAgeden
dc.subject*Epidemiology, Molecularen
dc.subjectFemaleen
dc.subjectGenotypeen
dc.subjectHepatitis B virus/*classification/*genetics/isolation & purificationen
dc.subjectHepatitis B, Chronic/*epidemiology/virologyen
dc.subjectHumansen
dc.subjectKorea/epidemiologyen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPhylogenyen
dc.subjectSequence Analysis, DNAen
dc.subjectSerotypingen
dc.titleMolecular epidemiology of hepatitis B virus (HBV) genotypes and serotypes in patients with chronic HBV infection in Koreaen
dc.typeArticleen
dc.contributor.AlternativeAuthor김홍-
dc.contributor.AlternativeAuthor지영미-
dc.contributor.AlternativeAuthor송병철-
dc.contributor.AlternativeAuthor신정우-
dc.contributor.AlternativeAuthor양수현-
dc.contributor.AlternativeAuthor문호숙-
dc.contributor.AlternativeAuthor김현주-
dc.contributor.AlternativeAuthor오은주-
dc.contributor.AlternativeAuthor윤정환-
dc.contributor.AlternativeAuthor김윤준-
dc.contributor.AlternativeAuthor이효석-
dc.contributor.AlternativeAuthor황응수-
dc.contributor.AlternativeAuthor차창용-
dc.contributor.AlternativeAuthor국윤호-
dc.contributor.AlternativeAuthor김범준-
dc.identifier.doi10.1159/000096313-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Microbiology (미생물학전공)Journal Papers (저널논문_미생물학전공)
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