Publications
Detailed Information
Inhibitory effects of glycitein on hydrogen peroxide induced cell damage by scavenging reactive oxygen species and inhibiting c-Jun N-terminal kinase
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Kyoung Ah | - |
dc.contributor.author | Zhang, Rui | - |
dc.contributor.author | Piao, Mei Jing | - |
dc.contributor.author | Lee, Kyoung Hwa | - |
dc.contributor.author | Kim, Bum Joon | - |
dc.contributor.author | Kim, So Young | - |
dc.contributor.author | Kim, Hee Sun | - |
dc.contributor.author | Kim, Dong Hyun | - |
dc.contributor.author | You, Ho Jin | - |
dc.contributor.author | Hyun, Jin Won | - |
dc.date.accessioned | 2010-01-07T06:45:38Z | - |
dc.date.available | 2010-01-07T06:45:38Z | - |
dc.date.issued | 2007-05-23 | - |
dc.identifier.citation | Free Radic Res. 2007 Jun;41(6):720-9. | en |
dc.identifier.issn | 1071-5762 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17516245 | - |
dc.identifier.uri | https://hdl.handle.net/10371/28482 | - |
dc.description.abstract | The present study investigated the cytoprotective properties of glycitein, a metabolite formed by the transformation of glycitin by intestinal microflora, against oxidative stress. Glycitein was found to scavenge intracellular reactive oxygen species (ROS), and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, and thereby preventing lipid peroxidation and DNA damage. Glycitein inhibited apoptosis of Chinese hamster lung fibroblast (V79-4) cells exposed to hydrogen peroxide (H(2)O(2)) via radical scavenging activity. Glycitein abrogated the activation of c-Jun N-terminal kinase (JNK) induced by H(2)O(2) treatment and inhibited DNA binding activity of activator protein-1 (AP-1), a downstream transcription factor of JNK. Taken together, these findings suggest that glycitein protected H(2)O(2) induced cell death in V79-4 cells by inhibiting ROS generation and JNK activation. | en |
dc.language.iso | en | en |
dc.publisher | Taylor & Francis | en |
dc.subject | Animals | en |
dc.subject | Antioxidants/pharmacology | en |
dc.subject | Apoptosis/*drug effects | en |
dc.subject | Blotting, Western | en |
dc.subject | Cells, Cultured/drug effects/metabolism | en |
dc.subject | Comet Assay | en |
dc.subject | Cricetinae | en |
dc.subject | Cytoprotection | en |
dc.subject | Electrophoretic Mobility Shift Assay | en |
dc.subject | Extracellular Signal-Regulated MAP Kinases/metabolism | en |
dc.subject | Fibroblasts/cytology/drug effects/metabolism | en |
dc.subject | Flow Cytometry | en |
dc.subject | Free Radical Scavengers/pharmacology | en |
dc.subject | Hydrogen Peroxide/*pharmacology | en |
dc.subject | Isoflavones/metabolism/*pharmacology | en |
dc.subject | JNK Mitogen-Activated Protein Kinases/*antagonists & inhibitors/metabolism | en |
dc.subject | Luciferases/metabolism | en |
dc.subject | Lung/cytology/drug effects/metabolism | en |
dc.subject | Mitogen-Activated Protein Kinase 9/metabolism | en |
dc.subject | Oxidants/*pharmacology | en |
dc.subject | Oxidative Stress | en |
dc.subject | Phytoestrogens/pharmacology | en |
dc.subject | Promoter Regions, Genetic/genetics | en |
dc.subject | Reactive Oxygen Species/*metabolism | en |
dc.subject | Transcription Factor AP-1/genetics/metabolism | en |
dc.title | Inhibitory effects of glycitein on hydrogen peroxide induced cell damage by scavenging reactive oxygen species and inhibiting c-Jun N-terminal kinase | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 강경아 | - |
dc.contributor.AlternativeAuthor | 이경화 | - |
dc.contributor.AlternativeAuthor | 김범준 | - |
dc.contributor.AlternativeAuthor | 김소영 | - |
dc.contributor.AlternativeAuthor | 김희선 | - |
dc.contributor.AlternativeAuthor | 김동현 | - |
dc.contributor.AlternativeAuthor | 유호진 | - |
dc.contributor.AlternativeAuthor | 현진원 | - |
dc.identifier.doi | 10.1080/10715760701241618 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.