Publications
Detailed Information
Cord blood KL-6, a specific lung injury marker, correlates with the subsequent development and severity of atypical bronchopulmonary dysplasia
Cited 0 time in
Web of Science
Cited 0 time in Scopus
- Authors
- Issue Date
- 2007-11-21
- Publisher
- Karger
- Citation
- Neonatology. 2008;93(4):223-9. Epub 2007 Nov 16.
- Keywords
- Biological Markers/blood ; Bronchopulmonary Dysplasia/*blood ; C-Reactive Protein/analysis ; Case-Control Studies ; Female ; Fetal Blood/*metabolism ; Gestational Age ; Humans ; Infant, Newborn ; Infant, Premature/*blood ; Male ; Mucin-1/*blood
- Abstract
- BACKGROUND: A considerable number of preterm infants may have been exposed to inflammation in utero and may be born with an inflamed lung. OBJECTIVES: To determine the impact of antenatal lung injury and inflammatory response on the pathogenesis of bronchopulmonary dysplasia (BPD) according to its clinical pattern, using KL-6 (as a lung injury marker) and C-reactive protein (CRP) (as a marker of inflammatory response). METHODS: In this case-control study, a total of 74 infants (<32 weeks of gestation) including BPD with minimal early lung disease ('atypical'; 21 infants), BPD with significant early lung disease ('classic'; 29 infants) and the non-BPD (24 infants) groups underwent KL-6 and CRP in cord blood determinations. RESULTS: The cord plasma KL-6 levels were significantly higher in the atypical and the total BPD groups than in the non-BPD group (median = 60.9 vs. 34.5 U/ml, p = 0.031; 43.5 vs. 34.5 U/ml, p = 0.02). However, the cord plasma CRP levels were not significantly different among the study groups. The cord plasma KL-6 levels in patients with atypical BPD were significantly higher in infants with moderate or severe BPD than in infants with mild BPD (median = 88.3 vs. 41.5 U/ml, p = 0.041) and were found to be significantly correlated with the duration of oxygen therapy (r = 0.502, p = 0.024). CONCLUSIONS: The present study shows that cord plasma KL-6, a specific lung injury marker, is increased and objectively reflects disease severity in atypical BPD.
- ISSN
- 1661-7819 (Electronic)
- Language
- English
- URI
- http://content.karger.com/produktedb/produkte.asp?typ=pdf&file=000111100
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18025794
https://hdl.handle.net/10371/28903
- Files in This Item:
- There are no files associated with this item.
- Appears in Collections:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.