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Cord blood KL-6, a specific lung injury marker, correlates with the subsequent development and severity of atypical bronchopulmonary dysplasia
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Do-Hyun | - |
dc.contributor.author | Kim, Han-Suk | - |
dc.contributor.author | Shim, So-Yeon | - |
dc.contributor.author | Lee, Jin-A | - |
dc.contributor.author | Choi, Chang Won | - |
dc.contributor.author | Kim, Ee-Kyung | - |
dc.contributor.author | Kim, Beyong Il | - |
dc.contributor.author | Choi, Jung-Hwan | - |
dc.date.accessioned | 2010-01-08T05:20:50Z | - |
dc.date.available | 2010-01-08T05:20:50Z | - |
dc.date.issued | 2007-11-21 | - |
dc.identifier.citation | Neonatology. 2008;93(4):223-9. Epub 2007 Nov 16. | en |
dc.identifier.issn | 1661-7819 (Electronic) | - |
dc.identifier.uri | http://content.karger.com/produktedb/produkte.asp?typ=pdf&file=000111100 | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18025794 | - |
dc.identifier.uri | https://hdl.handle.net/10371/28903 | - |
dc.description.abstract | BACKGROUND: A considerable number of preterm infants may have been exposed to inflammation in utero and may be born with an inflamed lung. OBJECTIVES: To determine the impact of antenatal lung injury and inflammatory response on the pathogenesis of bronchopulmonary dysplasia (BPD) according to its clinical pattern, using KL-6 (as a lung injury marker) and C-reactive protein (CRP) (as a marker of inflammatory response). METHODS: In this case-control study, a total of 74 infants (<32 weeks of gestation) including BPD with minimal early lung disease ('atypical'; 21 infants), BPD with significant early lung disease ('classic'; 29 infants) and the non-BPD (24 infants) groups underwent KL-6 and CRP in cord blood determinations. RESULTS: The cord plasma KL-6 levels were significantly higher in the atypical and the total BPD groups than in the non-BPD group (median = 60.9 vs. 34.5 U/ml, p = 0.031; 43.5 vs. 34.5 U/ml, p = 0.02). However, the cord plasma CRP levels were not significantly different among the study groups. The cord plasma KL-6 levels in patients with atypical BPD were significantly higher in infants with moderate or severe BPD than in infants with mild BPD (median = 88.3 vs. 41.5 U/ml, p = 0.041) and were found to be significantly correlated with the duration of oxygen therapy (r = 0.502, p = 0.024). CONCLUSIONS: The present study shows that cord plasma KL-6, a specific lung injury marker, is increased and objectively reflects disease severity in atypical BPD. | en |
dc.language.iso | en | - |
dc.publisher | Karger | en |
dc.subject | Biological Markers/blood | en |
dc.subject | Bronchopulmonary Dysplasia/*blood | en |
dc.subject | C-Reactive Protein/analysis | en |
dc.subject | Case-Control Studies | en |
dc.subject | Female | en |
dc.subject | Fetal Blood/*metabolism | en |
dc.subject | Gestational Age | en |
dc.subject | Humans | en |
dc.subject | Infant, Newborn | en |
dc.subject | Infant, Premature/*blood | en |
dc.subject | Male | en |
dc.subject | Mucin-1/*blood | en |
dc.title | Cord blood KL-6, a specific lung injury marker, correlates with the subsequent development and severity of atypical bronchopulmonary dysplasia | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김도현 | - |
dc.contributor.AlternativeAuthor | 김한석 | - |
dc.contributor.AlternativeAuthor | 심소연 | - |
dc.contributor.AlternativeAuthor | 이진아 | - |
dc.contributor.AlternativeAuthor | 최창원 | - |
dc.contributor.AlternativeAuthor | 김에경 | - |
dc.contributor.AlternativeAuthor | 김병일 | - |
dc.contributor.AlternativeAuthor | 최정환 | - |
dc.identifier.doi | 10.1159/111100 | - |
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