SHERP

Cerebral glucose metabolism in oculopalatal tremor

Cited 0 time in webofscience Cited 6 time in scopus
Authors
Moon, S Y; Cho, S S; Kim, Y K; Kim, S E; Kim, J H; Kim, J S
Issue Date
2007-11-17
Publisher
Blackwell Publishing
Citation
Eur J Neurol. 2008 Jan;15(1):42-9. Epub 2007 Nov 14.
Keywords
AdultAgedBrain/metabolism/physiopathology/radionuclide imagingFluorodeoxyglucose F18/diagnostic useFunctional Laterality/physiologyGlucose/*metabolismHumansMaleMiddle AgedMyoclonus/*metabolism/physiopathology/radionuclide imagingNeural Pathways/metabolism/physiopathology/radionuclide imagingOlivary Nucleus/pathology/physiopathologyPons/metabolism/physiopathology/radionuclide imagingPositron-Emission TomographyPredictive Value of TestsSensitivity and SpecificityThalamus/metabolism/physiopathology/radionuclide imagingTremor/*metabolism/physiopathology/radionuclide imaging
Abstract
No study adopted the statistical parametric mapping (SPM) analyses of (18)F-fluorodeoxy glucose (FDG) PET in a large number of patients with oculopalatal tremor (OPT). To determine regional cerebral glucose metabolism in patients with OPT, nine patients with OPT underwent FDG-PET of the brain. Their glucose metabolism was compared with that of 50 normal controls (NC) by using SPM analyses. Three patients had bilateral and six showed unilateral pseudohypertrophic degeneration of the inferior olivary nucleus (ION) on MRI. Compared with NC, OPT patients did not show any metabolic derangement in the anterolateral medulla where the pseudohypertrophic ION locates. Instead, six patients with unilateral ION changes had hypometabolism in ipsilesional pontine tegmentum and hypermetabolism in contralesional thalamus. Their metabolic changes did not depend on the lateralization of ION changes. Our study failed to present any metabolic evidence for the role of ION in the generation of OPT. In part, the failure might originate from the different pathomechanism between OPT and pure palatal tremor or sensitivity/specificity issues of PET and SPM analyses. But, our results suggest that impaired cell groups of the paramedian tract and thalamic tremor cells may contribute to the generation of OPT.
ISSN
1468-1331 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18005053

http://hdl.handle.net/10371/28912
DOI
https://doi.org/10.1111/j.1468-1331.2007.01997.x
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Nuclear Medicine (핵의학전공)Journal Papers (저널논문_핵의학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse