Cerebral glucose metabolism in oculopalatal tremor

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Moon, S Y; Cho, S S; Kim, Y K; Kim, S E; Kim, J H; Kim, J S
Issue Date
Blackwell Publishing
Eur J Neurol. 2008 Jan;15(1):42-9. Epub 2007 Nov 14.
AdultAgedBrain/metabolism/physiopathology/radionuclide imagingFluorodeoxyglucose F18/diagnostic useFunctional Laterality/physiologyGlucose/*metabolismHumansMaleMiddle AgedMyoclonus/*metabolism/physiopathology/radionuclide imagingNeural Pathways/metabolism/physiopathology/radionuclide imagingOlivary Nucleus/pathology/physiopathologyPons/metabolism/physiopathology/radionuclide imagingPositron-Emission TomographyPredictive Value of TestsSensitivity and SpecificityThalamus/metabolism/physiopathology/radionuclide imagingTremor/*metabolism/physiopathology/radionuclide imaging
No study adopted the statistical parametric mapping (SPM) analyses of (18)F-fluorodeoxy glucose (FDG) PET in a large number of patients with oculopalatal tremor (OPT). To determine regional cerebral glucose metabolism in patients with OPT, nine patients with OPT underwent FDG-PET of the brain. Their glucose metabolism was compared with that of 50 normal controls (NC) by using SPM analyses. Three patients had bilateral and six showed unilateral pseudohypertrophic degeneration of the inferior olivary nucleus (ION) on MRI. Compared with NC, OPT patients did not show any metabolic derangement in the anterolateral medulla where the pseudohypertrophic ION locates. Instead, six patients with unilateral ION changes had hypometabolism in ipsilesional pontine tegmentum and hypermetabolism in contralesional thalamus. Their metabolic changes did not depend on the lateralization of ION changes. Our study failed to present any metabolic evidence for the role of ION in the generation of OPT. In part, the failure might originate from the different pathomechanism between OPT and pure palatal tremor or sensitivity/specificity issues of PET and SPM analyses. But, our results suggest that impaired cell groups of the paramedian tract and thalamic tremor cells may contribute to the generation of OPT.
1468-1331 (Electronic)
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College of Medicine/School of Medicine (의과대학/대학원)Nuclear Medicine (핵의학전공)Journal Papers (저널논문_핵의학전공)
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