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Early up-regulation of CXC-chemokine expression is associated with strong cellular immune responses to murine skin xenografts

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dc.contributor.authorLee, Eun Mi-
dc.contributor.authorPark, Joon Oh-
dc.contributor.authorKim, Donghee-
dc.contributor.authorKim, Jae Young-
dc.contributor.authorOh, Kook-Hwan-
dc.contributor.authorPark, Chung-Gyu-
dc.contributor.authorOh, Byung Hee-
dc.contributor.authorKim, Suhnggwon-
dc.contributor.authorAhn, Curie-
dc.date.accessioned2010-01-08T05:26:04Z-
dc.date.available2010-01-08T05:26:04Z-
dc.date.issued2006-06-14-
dc.identifier.citationXenotransplantation. 2006 Jul;13(4):328-36.en
dc.identifier.issn0908-665X (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16768726-
dc.identifier.urihttp://hdl.handle.net/10371/28915-
dc.description.abstractBACKGROUND: The dynamic pattern of the cellular infiltration and mRNA expression of chemokines in rat-to-mouse skin xenografts were examined to gain an understanding of the possible role of chemokines in the stronger cellular immune responses to xenografts compared with the allo-response. METHODS: The mean survival time of the xenografts was approximately 2 days less than that of allografts (10.7 +/- 0.9 days vs. 8.9 +/- 0.7 days, P < 0.05). In comparison with the allografts, the xenografts were characterized by a very early infiltration of monocytes/macrophages (day 3) and a larger number of CD4+ and CD8+ cells, as well as neutrophil infiltration in the early phase (day 5), and larger number of CD8+ and CD11b+ cells, as well as macrophage infiltration, in the later phase (day 7). Xenografts showed stronger interferon (IFN)-inducible 10-kDa protein (IP-10) and monokine induced by IFN (MIG) mRNA expression levels, which appeared earlier than in the allografts. In the later phase, strong expression of regulated on activation, normal T cell expressed and secreted was observed. Cytokine mRNA expression in the xenografts could be summarized by higher expression of IFN-gamma, interleukin (IL)1beta, IL6, and transforming growth factor -beta1 mRNA than in the allografts. These results suggest that the early increased CXC-chemokine expression, such as IP-10 and MIG, which has been known to be mainly produced by macrophages, may play a critical role in the stronger cellular xenograft rejection compared with allograft rejection. Therefore, MIG antiserum or CXCR3 antiserum was administered to the rat skin-engrafted mice every other day until rejection. RESULTS: Compared with the control normal rabbit serum-treated mice, either the MIG antiserum- or CXCR3 antiserum-treated mice showed a delayed rejection of approximately 2 days (8.3 +/- 0.5 days vs. 10.6 +/- 0.5 days or 10.8 +/- 1.9 days, respectively, P < 0.05). CONCLUSION: Overall, these results suggest that the more aggressive rejection of xenografts compared with allografts is due to the earlier expression of CXC-chemokines, IP-10 and MIG, and subsequent adjuvant effects of proinflammatory cytokines.en
dc.language.isoenen
dc.publisherBlackwell Publishingen
dc.subjectAnimalsen
dc.subjectChemokine CCL5/genetics/immunologyen
dc.subjectChemokine CXCL10en
dc.subjectChemokine CXCL9en
dc.subjectChemokines, CXC/genetics/*immunologyen
dc.subjectFemaleen
dc.subjectGraft Rejection/immunologyen
dc.subjectImmunity, Cellularen
dc.subjectMiceen
dc.subjectMice, Inbred BALB Cen
dc.subjectMice, Inbred C57BLen
dc.subjectRatsen
dc.subjectReceptors, CXCR3en
dc.subjectReceptors, Chemokine/immunologyen
dc.subjectSkin Transplantation/*immunologyen
dc.subjectSpecific Pathogen-Free Organismsen
dc.subjectTransplantation, Heterologous/*immunologyen
dc.subjectTransplantation, Homologous/immunologyen
dc.subjectTransplantation, Isogeneic/immunologyen
dc.subjectUp-Regulationen
dc.titleEarly up-regulation of CXC-chemokine expression is associated with strong cellular immune responses to murine skin xenograftsen
dc.typeArticleen
dc.contributor.AlternativeAuthor이은미-
dc.contributor.AlternativeAuthor박준오-
dc.contributor.AlternativeAuthor김동희-
dc.contributor.AlternativeAuthor김재영-
dc.contributor.AlternativeAuthor오국환-
dc.contributor.AlternativeAuthor박정규-
dc.contributor.AlternativeAuthor오병희-
dc.contributor.AlternativeAuthor김성권-
dc.contributor.AlternativeAuthor안규리-
dc.identifier.doi10.1111/j.1399-3089.2006.00311.x-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Microbiology (미생물학전공)Journal Papers (저널논문_미생물학전공)
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