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Sentinel node identification rate, but not accuracy, is significantly decreased after pre-operative chemotherapy in axillary node-positive breast cancer patients

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dc.contributor.authorLee, See youn-
dc.contributor.authorKim, Eun Young-
dc.contributor.authorKang, Seok Hyung-
dc.contributor.authorKim, Seok Won-
dc.contributor.authorKim, Seok-Ki-
dc.contributor.authorKang, Keon Wook-
dc.contributor.authorKwon, Youngmee-
dc.contributor.authorShin, Kyung Hwan-
dc.contributor.authorKang, Han-Sung-
dc.contributor.authorRo, Jungsil-
dc.contributor.authorLee, Eun Sook-
dc.date.accessioned2010-01-08T05:37:12Z-
dc.date.available2010-01-08T05:37:12Z-
dc.date.issued2006-10-26-
dc.identifier.citationBreast Cancer Res Treat. 2007 May;102(3):283-8. Epub 2006 Oct 25.en
dc.identifier.issn0167-6806 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17063280-
dc.identifier.urihttp://hdl.handle.net/10371/28930-
dc.description.abstractBACKGROUND: The aim was to prove the low identification rate of sentinel lymph node biopsy (SNB) and to determine the feasibility of replacing axillary lymph node dissection (AND) in axillary lymph node positive patients after chemotherapy. METHODS: From October 2001 to July 2005, 875 consecutive patients with primary operable breast cancer underwent SNB and AND. Among them, 238 received pre-operative chemotherapy. We compared the identification rate, false negative rate (FNR), negative predictive value (NPV), and accuracy of SNB in clinically node-positive patients with or without chemotherapy. RESULTS: The identification rate was significantly lower in patients received chemotherapy (77.6%) than in those not received it (97.0%) (P<0.001). In those received the therapy, the FNR was 5.6%, the NPV was 86.8%, and the accuracy was 95.9%. In those not received therapy, the FNR was 7.4% and the accuracy was 92.6% (differences not statistically significant). CONCLUSION: The identification rate in confirmed axillary lymph node-positive patients was significantly lower in patients received pre-operative chemotherapy, but accuracy did not differ significantly between the two groups. Thus, for patients who achieve complete axillary clearance by chemotherapy, SNB could replace AND.en
dc.language.isoen-
dc.publisherSpringer Verlagen
dc.subjectAntineoplastic Agents/*therapeutic useen
dc.subjectAxillaen
dc.subjectBreast Neoplasms/drug therapy/*pathology/surgeryen
dc.subjectFalse Negative Reactionsen
dc.subjectFemaleen
dc.subjectHumansen
dc.subject*Lymph Node Excisionen
dc.subjectLymphatic Metastasis/*diagnosisen
dc.subjectMiddle Ageden
dc.subject*Neoadjuvant Therapyen
dc.subjectNeoplasm Stagingen
dc.subjectPredictive Value of Testsen
dc.subjectSensitivity and Specificityen
dc.subject*Sentinel Lymph Node Biopsyen
dc.titleSentinel node identification rate, but not accuracy, is significantly decreased after pre-operative chemotherapy in axillary node-positive breast cancer patientsen
dc.typeArticleen
dc.contributor.AlternativeAuthor이시연-
dc.contributor.AlternativeAuthor김은영-
dc.contributor.AlternativeAuthor강석형-
dc.contributor.AlternativeAuthor김석원-
dc.contributor.AlternativeAuthor김석기-
dc.contributor.AlternativeAuthor강건욱-
dc.contributor.AlternativeAuthor권영미-
dc.contributor.AlternativeAuthor신경환-
dc.contributor.AlternativeAuthor강한성-
dc.contributor.AlternativeAuthor노정실-
dc.contributor.AlternativeAuthor이은숙-
dc.identifier.doi10.1007/s10549-006-9330-9-
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College of Medicine/School of Medicine (의과대학/대학원)Nuclear Medicine (핵의학전공)Journal Papers (저널논문_핵의학전공)
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