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Bronchial washing yield before and after forceps biopsy in patients with endoscopically visible lung cancers

Cited 15 time in Web of Science Cited 16 time in Scopus
Authors
Lee, Hee Seok; Kwon, Sung Youn; Kim, Deog Kyeom; Yoon, Ho Il; Lee, Sang-Min; Lee, Jae Ho; Lee, Choon-Taek; Chung, Hee Sun; Han, Sung Koo; Shim, Young-Soo; Yim, Jae Joon
Issue Date
2007-02-15
Publisher
Wiley-Blackwell
Citation
Respirology. 2007 Mar;12(2):277-82.
Keywords
AdultAgedAged, 80 and overBiopsy/instrumentationBronchoalveolar Lavage/*methodsBronchoalveolar Lavage Fluid/*cytology*BronchoscopyDiagnosis, DifferentialFemaleFollow-Up StudiesHumansLung Neoplasms/*pathologyMaleMiddle AgedProspective Studies
Abstract
BACKGROUND AND OBJECTIVE: The need for routine use of bronchial washing in addition to forceps biopsy has been debated in the diagnosis of endoscopically visible lung tumours. Moreover, the optimal sequence for obtaining bronchial washing and forceps biopsy specimens from endoscopically visible tumours through a flexible bronchoscope has not been well established. METHODS: A multicentre 13-month prospective randomized study was performed. Two hundred and thirty consecutive patients with endoscopically visible tumours were randomly assigned into a bronchial washing before forceps biopsy (pre-biopsy) group and a bronchial washing after forceps biopsy (post-biopsy) group. Bronchial washing and forceps biopsy were performed according to the assigned sequence. RESULTS: Two hundred and seven patients with a definite cytological or histological diagnosis of lung cancer were included in the analyses. One hundred and three were in the pre-biopsy group and 104 were in the post-biopsy group. The diagnostic yield of bronchial washing was 57.3% (59/103) in the pre-biopsy group and 55.8% (58/104) in the post-biopsy group (P = 0.88). In addition, bronchial washing provided the diagnosis in six patients without definite diagnosis from forceps biopsy, and its addition to forceps biopsy significantly increased the overall diagnostic yield of bronchoscopy from 93.7% to 96.6% (P = 0.03). CONCLUSION: The sequence for performing bronchial washing before or after forceps biopsy did not affect the diagnostic yield of bronchial washing in patients with endoscopically visible lung cancers. However, bronchial washing led to a significant increase in the overall diagnostic yield of bronchoscopy in patients with lung cancers.
ISSN
1323-7799 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17298463

http://hdl.handle.net/10371/29008
DOI
https://doi.org/10.1111/j.1440-1843.2006.01001.x
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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