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The relationship of TRP channels to the pacemaker activity of interstitial cells of Cajal in the gastrointestinal tract

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Authors
Kim, B. J.; So, I.; Kim, K. W.
Issue Date
2006-05-17
Publisher
The Japanese Society of Smooth Muscle Research
Citation
J Smooth Muscle Res. 2006 Feb;42(1):1-7.
Keywords
AnimalsBiological Clocks/physiologyEnteric Nervous System/*cytologyGastrointestinal Tract/*innervationMiceMyocytes, Smooth Muscle/*cytologyTRPC Cation Channels/*physiology
Abstract
Interstitial cells of Cajal (ICCs) are a fundamental component of the pacemaker apparatus of the gastrointestinal (GI) tract. They have special properties that make them unique in their ability to generate and propagate slow waves in gastrointestinal smooth muscle. The pacemaker current that generates slow waves is initially due to a voltage-independent, Ca(2+)-inhibited, non-selective cationic conductance in ICC. The classical transient receptor potential (TRPC) channel 4 was suggested as a molecular candidate for the nonselective cation channel (NSCC) responsible for the pacemaker activity. We have shown that TRPC4-/- mice display normal slow waves and suggest that TRPC4 might be an essential component of the NSCC activated by muscarinic stimulation. Finally, we suggest that TRPM7 is the molecular candidate for the NSCC responsible for pacemaker activity in ICCs on the basis of electrophysiological, molecular biological, and immunohistochemical experiments.
ISSN
0916-8737 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16702759

http://hdl.handle.net/10371/29031
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Physiology (생리학교실)Journal Papers (저널논문_생리학교실)
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